ZDHHC22

ZDHHC22 encodes zinc finger DHHC-type palmitoyltransferase 22 (DHHC22), a member of the DHHC palmitoyltransferase family. It catalyzes S-palmitoylation—a post-translational modification that attaches palmitic acid to target proteins, regulating their subcellular localization, stability, and signaling interactions.
DHHC22 participates in neuronal signaling pathways, modifying synaptic proteins to influence plasticity. Dysregulation is linked to neurological disorders (e.g., autism spectrum disorders) and certain cancers, via aberrant palmitoylation of oncogenic or tumor-suppressive proteins. Preclinical studies explore small-molecule inhibitors targeting DHHC22 to correct pathological palmitoylation, though no clinical drugs are available yet.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The following ZDHHC22 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ZDHHC22 Proteins

ZDHHC22 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF822734HU	Recombinant Human Putative palmitoyltransferase ZDHHC22 (ZDHHC22)	in vitro E.coli expression system
CSB-YP822734HU1 CSB-EP822734HU1 CSB-BP822734HU1 CSB-MP822734HU1 CSB-EP822734HU1-B	Recombinant Human Putative palmitoyltransferase ZDHHC22 (ZDHHC22), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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ZDHHC22

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