ZDHHC8

ZDHHC8 encodes the Zinc Finger DHHC-Type Palmitoyltransferase 8 protein, also commonly known as ZNF809. This protein functions as a palmitoyltransferase, which attaches palmitic acid to specific cysteine residues of target proteins. This palmitoylation process is crucial for protein trafficking, stability, and membrane localization. It is involved in several signaling pathways, including those related to neuronal development and function.
Mutations in ZDHHC8 are associated with intellectual disability and other neurological disorders. Given its role in these diseases, ZDHHC8 has emerged as a potential drug target. Current drug - discovery efforts are focused on developing compounds that can modulate its palmitoyltransferase activity to treat related neurological conditions.