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| Code | CSB-EP013456HU |
| Product Type | Recombinant Protein |
| Size | US$1198 |
| Uniprot No. | P27361 |
| Relevance | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangents. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and se to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elents (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | ERT2Extracellular domain signal-regulated kinase 1 ;ERK-1Insulin-stimulated MAP2 kinase;MAP kinase isoform p44 ;p44-MAPKMicrotubule-associated protein 2 kinasep44-ERK1 |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | GGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP |
| Research Area | Cell Cycle |
| Source | E.coli |
| Gene Names | MAPK3 |
| Expression Region | 11-379aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 46.3kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. |
| Subcellular Location | Cytoplasm, Nucleus, Membrane, caveola |
| Protein Families | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily |
| Database Links |
HGNC: 6877 OMIM: 601795 KEGG: hsa:5595 STRING: 9606.ENSP00000263025 UniGene: Hs.861 |
| Pathway |
cAMP signaling pathway
Chemokine signaling pathway ErbB signaling pathway Estrogen signaling pathway HIF-1 signaling pathway MAPK signaling pathway Melanogenesis mTOR signaling pathway PI3K-Akt signaling pathway TGF-beta signaling pathway VEGF signaling pathway Focal adhesion Gap junction Lipids and Inflammation in Atherogenesis Regulation of actin cytoskeleton TNF signaling pathway Vascular smooth muscle contraction Adherens junction Autophagy Cellular senescence MAPK Erk pathway Ras signaling pathway Signaling pathways regulating pluripotency of stem cells B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis IL-17 signaling pathway Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway Rap1 signaling pathway Sphingolipid signaling pathway Excitatory synapse pathway Glutamatergic synapse Neurotrophin signaling pathway |
MAPK3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA013456GA01HU | MAPK3 Antibody | Human,Mouse,Rat,Zebrafish | ELISA,WB,IHC |
| CSB-PA013456LB01HU | MAPK3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013456LC01HU | MAPK3 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA013456LD01HU | MAPK3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA245959 | Phospho-MAPK3 (Thr202) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA089297 | Phospho-MAPK3 (Tyr204) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA955942 | MAPK3 (Ab-202) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA070105 | MAPK3 (Ab-204) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA876456 | Phospho-MAPK3/MAPK1 (Thr202/Tyr204) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA272447 | MAPK3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA931769 | MAPK3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002417 | MAPK3 Antibody | Human,Mouse,Rat | WB,IF,ELISA |
| CSB-PA037845 | MAPK3 Antibody | Human | ELISA,WB,IHC |
| CSB-RA013456A185phHU | Phospho-MAPK3 (T202) + MAPK1 (T185) Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA321775 | MAPK3 Antibody | Human,Mouse,Rat | IHC,ELISA |
MAPK3 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA013456LA01HU | MAPK3 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
MAPK3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP013456HU CSB-BP013456HU CSB-MP013456HU |
Recombinant Human Mitogen-activated protein kinase 3(MAPK3) | Yeast Baculovirus Mammalian cell |
Recombinant Rabbit Apolipoprotein E(APOE),partial
Express system: E.coli
Species: Oryctolagus cuniculus (Rabbit)
Recombinant Rat Sulfotransferase 1A1(Sult1a1)
Express system: E.coli
Species: Rattus norvegicus (Rat)
Recombinant Human Transcription initiation factor IIA subunit 2(GTF2A2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Apolipoprotein B-100(APOB),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Bovine L-2-hydroxyglutarate dehydrogenase, mitochondrial(L2HGDH)
Express system: E.coli
Species: Bos taurus (Bovine)
Recombinant Human Transcription cofactor vestigial-like protein 3(VGLL3)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Laminin subunit alpha-5(LAMA5),partial
Express system: E.coli
Species: Homo sapiens (Human)
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