Transmembrane protein series five: Human leukocyte antigen (HLA)

What is Human leukocyte antigen?

Transmembrane proteins cross the phospholipid bilayer of the membrane, which determines the strong hydrophobicity of the transmembrane region. The transmembrane region of a transmembrane protein is completely or partially inserted into the membrane. The diversity of transmembrane proteins determines the diversity of their functional characteristics. It has the ability of material transport and signal transduction. In addition, transmembrane proteins also play an important role in the immune response.

Human leukocyte antigen is a kind of transmembrane protein, which is a protein or antigen present on the cell surface of the body. It plays a key role in the body's immune defense. The HLA system and MHC help the body's immune system distinguish between autologous substances and foreign or non-autologous substances.

Distribution of Human leukocyte antigen (HLA) in the population

HLA antigen has different distribution in different nationalities. Take HLA-B*27 as an example. In the US Columbia, Canadian coastal Indians and Canadian haida people, its positive rate is as high as 50%; among caucasians in Europe and the United States, the B27 positive rate was 6 to 8 percent; while the positive rate of B27 in Japanese and African blacks was less than 1%.

Human leukocyte antigen (HLA) application

The clinical application of HLA is mainly the matching of donor and recipient in organ transplantation and blood transfusion.

In organ transplantation, the donor and the recipient must have the same or matching HLA gene, so that the donor tissue is not attacked or rejected by the recipient's immune system.

In clinical transfusion, allogeneic HLA immunity causes various problems in transfusion therapy, such as platelet transfusion refractoriness, fever-induced non-hemolytic transfusion reaction, transfusion-related acute lung injury, transfusion-related graft-versus host disease, etc. Therefore, HLA detection is necessary.

Human leukocyte antigen (HLA) and disease

The HLA gene is associated with autoimmune diseases and cancer.

Many studies have shown that HLA is associated with HIV disease. In addition, HLA is strongly associated with recurrent miscarriage during pregnancy, pre-eclampsia, or hemolytic disease in the newborn. HLA is also one of the causes of drug sensitivity.

If you are interested in this topic, and want to know more details, like Antigen Processing Pathway, Population Distribution, Polymorphism of HLA, etc., please read the article, Human Leukocyte Antigen: Distinguish between Friend and Foe.

In your experiment, you may need HLA products to assist your research. CUSABIO can help you. We have established a special transmembrane protein expression system. HLA related products are listed as follows:

Hot Products

Human leukocyte antigen (HLA) related proteins for your research

Human leukocyte antigen (HLA) related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
HLA-E HLA-E Antibody, HRP conjugated CSB-PA320269LB01HU Human ELISA
HLA-E HLA-E Antibody CSB-PA320269LA01HU Human ELISA
HLA-DRB3 HLA-DRB3 Antibody, FITC conjugated CSB-PA302920LC01HU Human ELISA
HLA-DRB3 HLA-DRB3 Antibody, Biotin conjugated CSB-PA302920LD01HU Human ELISA
HLA-DRB3 HLA-DRB3 Antibody, HRP conjugated CSB-PA302920LB01HU Human ELISA
HLA-DRB3 HLA-DRB3 Antibody CSB-PA302920LA01HU Human, Mouse ELISA, WB, IF
HLA-DRB3 HLA-DRB3 Antibody CSB-PA302920KA01HU Human, Mouse, Rat ELISA, WB, IHC
HLA-DRA HLA-DRA Antibody CSB-PA010497KA01HU Human, Mouse, Rat ELISA, WB, IHC
CD38 CD38 Antibody CSB-PA004929ESR1HU Human ELISA, IHC
CD37 CD37 Antibody, Biotin conjugated CSB-PA004928LD01HU Human ELISA
CD37 CD37 Antibody, FITC conjugated CSB-PA004928LC01HU Human ELISA
CD37 CD37 Antibody, HRP conjugated CSB-PA004928LB01HU Human ELISA
CD37 CD37 Antibody CSB-PA004928LA01HU Human, Mouse ELISA, WB, IHC, IF
HLA-DRB4 HLA-DRB4 Antibody, Biotin conjugated CSB-PA03909D0Rb Human ELISA
HLA-DRB4 HLA-DRB4 Antibody, FITC conjugated CSB-PA03909C0Rb Human ELISA
HLA-DRB4 HLA-DRB4 Antibody, HRP conjugated CSB-PA03909B0Rb Human ELISA
HLA-DRB4 HLA-DRB4 Antibody CSB-PA03909A0Rb Human ELISA, WB, IHC
HLA-DRA HLA-DRA Antibody, Biotin conjugated CSB-PA17939D0Rb Human ELISA
HLA-DRA HLA-DRA Antibody, FITC conjugated CSB-PA17939C0Rb Human ELISA
HLA-DRA HLA-DRA Antibody, HRP conjugated CSB-PA17939B0Rb Human ELISA
HLA-DRA HLA-DRA Antibody CSB-PA17939A0Rb Human ELISA, IHC
HLA-DQB1 HLA-DQB1 Antibody, Biotin conjugated CSB-PA14849D0Rb Human ELISA
HLA-DQB1 HLA-DQB1 Antibody, FITC conjugated CSB-PA14849C0Rb Human ELISA
HLA-DQB1 HLA-DQB1 Antibody, HRP conjugated CSB-PA14849B0Rb Human ELISA
HLA-DQB1 HLA-DQB1 Antibody CSB-PA14849A0Rb Human, Mouse ELISA, WB, IHC
HLA-DQA1 HLA-DQA1 Antibody, Biotin conjugated CSB-PA14839D0Rb Human ELISA, IHC
HLA-DQA1 HLA-DQA1 Antibody, FITC conjugated CSB-PA14839C0Rb Human ELISA
HLA-DQA1 HLA-DQA1 Antibody, HRP conjugated CSB-PA14839B0Rb Human ELISA
HLA-DQA1 HLA-DQA1 Antibody CSB-PA14839A0Rb Human ELISA, IHC
HLA-E HLA-E Antibody, FITC conjugated CSB-PA320269LC01HU Human ELISA
HLA-E HLA-E Antibody, Biotin conjugated CSB-PA320269LD01HU Human ELISA
HLA-F HLA-F Antibody CSB-PA335552LA01HU Human ELISA, IF
HLA-F HLA-F Antibody, HRP conjugated CSB-PA335552LB01HU Human ELISA
HLA-F HLA-F Antibody, FITC conjugated CSB-PA335552LC01HU Human ELISA
HLA-F HLA-F Antibody, Biotin conjugated CSB-PA335552LD01HU Human ELISA

Human leukocyte antigen (HLA) related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
HLA-B Human leucocyte antigen B27,HLA-B27 ELISA Kit CSB-E08607h serum, urine, cerebrospinal fluid (CSF) 0.078 ng/mL
HLA-DRA Human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) ELISA kit CSB-EL010497HU serum, plasma, tissue homogenates 4.68 pg/mL
HLA-E Human major histocompatibility complex, class I, E (HLA-E) ELISA kit CSB-EL010507HU serum, plasma, cell culture supernates, tissue homogenates 7.81 pg/mL

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