Transmembrane protein series five: Human leukocyte antigen (HLA)

What is Human leukocyte antigen?

Transmembrane proteins cross the phospholipid bilayer of the membrane, which determines the strong hydrophobicity of the transmembrane region. The transmembrane region of a transmembrane protein is completely or partially inserted into the membrane. The diversity of transmembrane proteins determines the diversity of their functional characteristics. It has the ability of material transport and signal transduction. In addition, transmembrane proteins also play an important role in the immune response.

Human leukocyte antigen is a kind of transmembrane protein, which is a protein or antigen present on the cell surface of the body. It plays a key role in the body's immune defense. The HLA system and MHC help the body's immune system distinguish between autologous substances and foreign or non-autologous substances.

Distribution of Human leukocyte antigen (HLA) in the population

HLA antigen has different distribution in different nationalities. Take HLA-B*27 as an example. In the US Columbia, Canadian coastal Indians and Canadian haida people, its positive rate is as high as 50%; among caucasians in Europe and the United States, the B27 positive rate was 6 to 8 percent; while the positive rate of B27 in Japanese and African blacks was less than 1%.

Human leukocyte antigen (HLA) application

The clinical application of HLA is mainly the matching of donor and recipient in organ transplantation and blood transfusion.

In organ transplantation, the donor and the recipient must have the same or matching HLA gene, so that the donor tissue is not attacked or rejected by the recipient's immune system.

In clinical transfusion, allogeneic HLA immunity causes various problems in transfusion therapy, such as platelet transfusion refractoriness, fever-induced non-hemolytic transfusion reaction, transfusion-related acute lung injury, transfusion-related graft-versus host disease, etc. Therefore, HLA detection is necessary.

Human leukocyte antigen (HLA) and disease

The HLA gene is associated with autoimmune diseases and cancer.

Many studies have shown that HLA is associated with HIV disease. In addition, HLA is strongly associated with recurrent miscarriage during pregnancy, pre-eclampsia, or hemolytic disease in the newborn. HLA is also one of the causes of drug sensitivity.

If you are interested in this topic, and want to know more details, like Antigen Processing Pathway, Population Distribution, Polymorphism of HLA, etc., please read the article, Human Leukocyte Antigen: Distinguish between Friend and Foe.

In your experiment, you may need HLA products to assist your research. CUSABIO can help you. We have established a special transmembrane protein expression system. HLA related products are listed as follows:

Hot Products

Human leukocyte antigen (HLA) related proteins for your research

Target Product Name Code Expression System
HLA-B Recombinant Human HLA-B protein(HLA-B),partial CSB-RP150894h E.coli
HLA-C Recombinant Human HLA-C protein(HLA-C),partial CSB-RP150994h E.coli
HLA-DRA Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA),partial CSB-EP360793HU1 E.coli
HLA-DQA1 Recombinant Human HLA class II histocompatibility antigen, DQ alpha 1 chain(HLA-DQA1),partial CSB-RP148394h E.coli
HLA-DQA2 Recombinant Human HLA class II histocompatibility antigen, DQ alpha 2 chain(HLA-DQA2),partial CSB-RP148294h E.coli
HLA-DPA1 Recombinant Human HLA class II histocompatibility antigen, DP alpha 1 chain(HLA-DPA1),partial CSB-RP148194h E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-MP010509HU Mammalian cell
HLA-DPB1 Recombinant Human HLA class II histocompatibility antigen, DP beta 1 chain(HLA-DPB1),partial CSB-RP148094h E.coli
HLA-DRB1 Recombinant Human HLA class II histocompatibility antigen, DRB1-1 beta chain(HLA-DRB1),partial CSB-EP361230HU E.coli
HLA-DRA Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA) CSB-EP360793HU E.coli
HLA-DQB1 Recombinant Human HLA class II histocompatibility antigen,DQ beta 1 chain(HLA-DQB1),partial CSB-EP355782HU E.coli
HLA-DMA Recombinant Human HLA-DMA protein(HLA-DMA),partial CSB-EP338892HU E.coli
HLA-DMB Recombinant Human HLA class II histocompatibility antigen, DM beta chain(HLA-DMB),partial CSB-EP333326HU E.coli
HLA-A Recombinant Human HLA class I histocompatibility antigen,A-1 alpha chain(HLA-A),partial CSB-EP328989HU E.coli
HLA-E Recombinant Human HLA class I histocompatibility antigen, alpha chain E(HLA-E) ,partial CSB-EP320269HU E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-EP010509HUb0 E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-EP010509HUa2 E.coli
HLA-DRA Recombinant Human HLA class II histocompatibility antigen, DR alpha chain(HLA-DRA) CSB-YP360793HU Yeast
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G),partial CSB-EP010509HU1 E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-EP010509HU E.coli
HLA-E Recombinant Human HLA class I histocompatibility antigen, alpha chain E(HLA-E),partial CSB-BP320269HU Baculovirus
HLA-A Recombinant Human HLA class I histocompatibility antigen,A-1 alpha chain(HLA-A),partial CSB-EP328989HUb1 E.coli
HLA-A Recombinant Human HLA class I histocompatibility antigen, A alpha chain(HLA-A),partial CSB-BP328989HU Baculovirus
HLA-A Recombinant Human HLA class I histocompatibility antigen, A alpha chain(HLA-A),partial CSB-EP3499HU E.coli
HLA-DRB1 Recombinant Human HLA class II histocompatibility antigen, DRB1-3 chain(HLA-DRB1),partial CSB-EP365687HU E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G),partial CSB-EP010509HU1a6 E.coli
HLA-DRB5 Recombinant Human HLA class II histocompatibility antigen, DR beta 5 chain(HLA-DRB5),partial CSB-EP657235HU E.coli
HLA-G Recombinant Human HLA class I histocompatibility antigen, alpha chain G(HLA-G) CSB-YP010509HU Yeast
HLA-DRB1 Recombinant Human HLA class II histocompatibility antigen, DRB1-12 beta chain(HLA-DRB1) CSB-EP846484HU E.coli

Human leukocyte antigen (HLA) related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
HLA-H HLA-H Antibody CSB-PA958630 Human ELISA, WB
HLA-H HLA-H Antibody CSB-PA009213 Human ELISA, WB
HLA-DQB1/HLA-DQB2 HLA-DQB1/HLA-DQB2 Antibody CSB-PA005915 Human ELISA, WB
HLA-DPA1 HLA-DPA1 Antibody CSB-PA14819A0Rb Human ELISA, WB, IF
HLA-DPA1 HLA-DPA1 Antibody CSB-PA177845 Human ELISA, WB
HLA-DOB HLA-DOB Antibody CSB-PA002935 Human ELISA, WB
HLA-DPA1 HLA-DPA1 Antibody CSB-PA009209 Human ELISA, WB
HLA-DOB HLA-DOB Antibody CSB-PA270928 Human ELISA, WB
HLA-A HLA-A Antibody CSB-PA906516 Human ELISA, WB
HLA-A HLA-A Antibody CSB-PA398166 Human ELISA, WB
HLA-DMB HLA-DMB Antibody CSB-PA561724 Human ELISA, IHC
HLA-DOA HLA-DOA Antibody CSB-PA002934 Human WB, IHC, ELISA
HLA-DOA HLA-DOA Antibody CSB-PA113671 Human ELISA, WB
HLA-DOA HLA-DOA Antibody CSB-PA356784ESR1HU Human ELISA, IHC

Human leukocyte antigen (HLA) related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
HLA-DRA Human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) ELISA kit CSB-EL010497HU serum, plasma, tissue homogenates 4.68 pg/mL
HLA-G Human leukocyte antigen G,HLA-G ELISA Kit CSB-E09401h serum, plasma, tissue homogenates 0.31 ng/mL
HLA-B27 Human leucocyte antigen B27,HLA-B27 ELISA Kit CSB-E08607h serum, urine, cerebrospinal fluid (CSF) 0.078 ng/mL
HLA-E Human major histocompatibility complex, class I, E (HLA-E) ELISA kit CSB-EL010507HU serum, plasma, cell culture supernates, tissue homogenates 7.81 pg/mL

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