Transmembrane protein series two: Ion Channels

What are Ion Channels?

Transmembrane proteins are widely present in organisms and play important physiological functions. Its function differs significantly depending on the type of difference. It constitutes a variety of ion channels, which inputs nutrients and some inorganic electrolytes into cells, and excretes toxic or useless metabolites from cells.

Ion channels are commonly called channel proteins. Ion channels regulate the opening and closing of ion channels to regulate the ability of corresponding substances to enter and exit cells, thereby regulating various key physiological processes of the living system. Almost all cellular processes rely on ion channels.

Ion channel function

  • Substance absorption
  • Osmotic pressure regulation
  • Electrical impulse formation: The various sensory mechanisms of animals, such as vision, taste, smell and temperature perception, are related to changes in potential caused by ion channels.
  • Signal transmission: Certain ions (Ca2+, K+, etc.) in the cytoplasm rapidly increase in concentration to form signal stimulation, further affecting downstream signaling pathways. Ion channels are the primary channel for adjusting ion concentration.

Ion channels and diseases

Ion channel genetic variation and dysfunction are associated with the development and progression of many diseases. The ion channel disease, which is well studied, mainly involves the fields of potassium, sodium, calcium and chloride channels.

Ion channels have a certain relationship with tumors. Ion channels also play a conservative role in development.

To learn more about ion channels, there may be information you want to know in this article: A Switch that Controls the Entry and Exit of Ions.

Ion channels and their correlation with nerves, cardiovasculars, immune diseases, and cancer make ion channels an important target for drug design. Different target drugs can be designed according to different types of channels.

These ion channel related products produced by CUSABIO provide convenience for your research. At present, we have produced more than 1200 ion channel related products: 1106 antibody products, 70 protein products, 37 ELISA kits.

Hot Products

Ion channels related proteins for your research

Target Product Name Code Expression System
KCNJ10 Recombinant Human ATP-sensitive inward rectifier potassium channel 10(KCNJ10) ,partial CSB-EP012048HU E.coli
KCNJ1 Recombinant Human ATP-sensitive inward rectifier potassium channel 1(KCNJ1),partial CSB-YP012047HU Yeast
KCNJ1 Recombinant Human ATP-sensitive inward rectifier potassium channel 1(KCNJ1),partial CSB-EP012047HU E.coli
KCND2 Recombinant Human Potassium voltage-gated channel subfamily D member 2(KCND2),partial CSB-YP012023HU Yeast
KCND1 Recombinant Human Potassium voltage-gated channel subfamily D member 1(KCND1),partial CSB-YP012022HU Yeast
KCND1 Recombinant Human Potassium voltage-gated channel subfamily D member 1 protein(KCND1),partial CSB-EP012022HU E.coli
KCNAB2 Recombinant Human Voltage-gated potassium channel subunit beta-2(KCNAB2) CSB-EP012014HU E.coli
KCNA1 Recombinant Human Potassium voltage-gated channel subfamily A member 1 protein(KCNA1),partial CSB-EP012005HU E.coli
HTR3E Recombinant Human 5-hydroxytryptamine receptor 3E(HTR3E),partial CSB-CF010894HU in vitro E.coli expression system
HTR3D Recombinant Human 5-hydroxytryptamine receptor 3D(HTR3D),partial CSB-CF747864HU in vitro E.coli expression system
GRIN2A Recombinant Human Glutamate receptor ionotropic, NMDA 2A(GRIN2A),partial CSB-EP618634HU1 E.coli
GRIN1 Recombinant Human Glutamate [NMDA] receptor subunit zeta-1(GRIN1),partial CSB-EP009911HU E.coli
GRIA3 Recombinant Human Glutamate receptor 3(GRIA3),partial CSB-YP009900HU Yeast
GRIA3 Recombinant Human Glutamate receptor 3(GRIA3),partial CSB-EP009900HU E.coli
GABRA4 Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-4(GABRA4),partial CSB-EP009143HU E.coli
FXYD3 Recombinant Human FXYD domain-containing ion transport regulator 3(FXYD3),Partial CSB-EP622789HU E.coli
FXYD2 Recombinant Human Sodium/potassium-transporting ATPase subunit gamma(FXYD2) CSB-EP009090HU E.coli
CYBB RecombinantHumanCytochromeb-245heavychain(CYBB),partial CSB-YP006325HU1 Yeast
EGF Recombinant Human Pro-epidermal growth factor(EGF) ,partial CSB-RP062444h E.coli
CYBB Recombinant Human Cytochrome b-245 heavy chain(CYBB),partial CSB-EP006325HU1a2 E.coli
CTNNB1 Recombinant Human Catenin beta-1(CTNNB1) CSB-YP006169HU Yeast
CTNNB1 Recombinant Human Catenin beta-1(CTNNB1) CSB-EP006169HU E.coli
CNGA4 Recombinant Human Cyclic nucleotide-gated cation channel alpha-4(CNGA4) CSB-CF808540HU in vitro E.coli expression system
CLIC4 Recombinant Human Chloride intracellular channel protein 4(CLIC4) CSB-EP005549HU E.coli
CAV3 Recombinant Human Caveolin-3(CAV3) CSB-EP004573HU E.coli
CALM1 Recombinant Human Calmodulin(CALM1) CSB-EP004445HU E.coli
ATP6V1F Recombinant Human V-type proton ATPase subunit F(ATP6V1F) CSB-RP015744h E.coli
ATP6V1G1 Recombinant Human V-type proton ATPase subunit G 1(ATP6V1G1) CSB-RP001344h E.coli
ATP6V0D1 Recombinant Human V-type proton ATPase subunit d 1(ATP6V0D1) CSB-EP002390HU E.coli
ANXA5 Recombinant Human Annexin A5(ANXA5) CSB-YP001846HU Yeast
ANXA5 Recombinant Human Annexin A5(ANXA5) CSB-YP001846HU Yeast
ANXA2 Recombinant Human Annexin A2(ANXA2) CSB-EP001840HUb2 E.coli
ANXA2 Recombinant Human Annexin A2(ANXA2) CSB-EP001840HUa0 E.coli
ANXA2 Recombinant Human Annexin A2(ANXA2) CSB-EP001840HU E.coli
ANXA2 Recombinant Human Annexin A2(ANXA2) CSB-EP001840HUe0 E.coli
YWHAQ Recombinant Human 14-3-3 protein theta(YWHAQ) CSB-EP026290HU E.coli
YWHAH Recombinant Human 14-3-3 protein eta(YWHAH),partial CSB-RP021744h E.coli
UCP1 Recombinant Human Mitochondrial brown fat uncoupling protein 1(UCP1) CSB-YP025554HU Yeast
UCP1 Recombinant Human Mitochondrial brown fat uncoupling protein 1(UCP1) CSB-EP025554HU E.coli
TRPA1 Recombinant Human Transient receptor potential cation channel subfamily A member 1(TRPA1),partial CSB-EP025074HU E.coli
SLC8A1 Recombinant Human Sodium/calcium exchanger 1 (SLC8A1),partial CSB-YP021723HU Yeast
RYR3 Recombinant Human Ryanodine receptor 3(RYR3),partial CSB-EP020621HU E.coli
RYR1 Recombinant Human Ryanodine receptor 1(RYR1),partial CSB-EP020619HU E.coli
PRKCSH Recombinant Human Glucosidase 2 subunit beta(PRKCSH),partial CSB-RP029254h E.coli
NCS1 Recombinant Human Neuronal calcium sensor 1(NCS1) CSB-EP008983HU E.coli
KCNMA1 Recombinant Human Calcium-activated potassium channel subunit alpha-1(KCNMA1),partial CSB-EP614255HU E.coli
KCNK3 Recombinant Human Potassium channel subfamily K member 3(KCNK3) CSB-CF012071HU in vitro E.coli expression system
KCNK2 Recombinant Human Potassium channel subfamily K member 2(KCNK2),partial CSB-YP012070HU Yeast
KCNJ10 Recombinant Human ATP-sensitive inward rectifier potassium channel 10(KCNJ10) CSB-CF012048HU in vitro E.coli expression system

Ion channels related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
ANO2 ANO2 Antibody CSB-PA001813GA01HU Human, Mouse, Rat ELISA, WB, IF
ANXA2 ANXA2 Antibody CSB-PA001840GA01HU Human, Mouse, Rat ELISA, WB, IHC
ANXA7 ANXA7 Antibody CSB-PA001848GA01HU Human, Mouse, Rat ELISA, WB, IHC
AP2M1 AP2M1 Antibody CSB-PA00627A0Rb Human, Mouse, Rat ELISA, WB, IHC
ARRB1 ARRB1 Antibody CSB-PA002134GA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
ATP1B1 ATP1B1 Antibody CSB-PA002326LA01HU Human, Rat, Mouse ELISA, WB, IHC, IF
CACNA1B CACNA1B Antibody CSB-PA004398GA01HU Human, Mouse, Rat ELISA, WB, IHC
CAMK2D CAMK2D Antibody CSB-PA004467GA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
CASQ2 CASQ2 Antibody CSB-PA004557GA01HU Human, Mouse, Rat ELISA, WB, IHC
CAV1 CAV1 Antibody CSB-PA004571GA01HU Human, Mouse, Rat ELISA, WB, IHC
CHP1 CHP1 Antibody CSB-PA860773LA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
CHRNA3 CHRNA3 Antibody CSB-PA005389GA01HU Human, Mouse, Rat ELISA, WB, IHC
CHRNB1 CHRNB1 Antibody CSB-PA005395GA01HU Human, Mouse, Rat ELISA, WB, IHC
CIB1 CIB1 Antibody CSB-PA005426GA01HU Human, Mouse, Rat ELISA, WB, IHC
CLCNKA CLCNKA Antibody CSB-PA005487GA01HU Human, Mouse, Rat ELISA, WB, IHC
CLIC1 CLIC1 Antibody CSB-PA005545GA01HU Human, Mouse, Rat ELISA, IHC, IF
CTNNB1 CTNNB1 Antibody CSB-PA006169GA01HU Human, Mouse, Rat, Zebrafish ELISA, WB, IHC
CYBB CYBB Antibody CSB-PA006325KA01HU Human, Mouse, Rat ELISA, WB, IHC
DIAPH1 DIAPH1 Antibody CSB-PA006890GA01HU Human, Mouse, Rat ELISA, WB, IF
FXYD2 FXYD2 Antibody CSB-PA009090GA01HU Human, Mouse, Rat ELISA, WB, IHC
FXYD6 FXYD6 Antibody CSB-PA009094GA01HU Human, Mouse, Rat ELISA, WB, IHC
GABRG2 GABRG2 Antibody CSB-PA009152GA01HU Human, Mouse, Rat ELISA, WB, IF
GRIA3 GRIA3 Antibody CSB-PA009900KA01HU Human, Mouse, Rat ELISA, WB, IHC
GRID1 GRID1 Antibody CSB-PA009902GA01HU Human, Mouse, Rat ELISA, WB, IHC
GRIN2A GRIN2A Antibody CSB-PA14129A0Rb Human, Mouse, Rat ELISA, WB, IHC, IF
HTR3A HTR3A Antibody CSB-PA010890GA01HU Human, Mouse, Rat ELISA, WB, IHC
KCNA1 KCNA1 Antibody CSB-PA012005LA01HU Human, Mouse, Rat ELISA, WB, IF
KCNAB1 KCNAB1 Antibody CSB-PA012013GA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
KCNIP1 KCNIP1 Antibody CSB-PA012043GA01HU Human, Mouse, Rat ELISA, WB, IHC
KCNJ11 KCNJ11 Antibody CSB-PA012049GA01HU Human, Mouse, Rat ELISA, WB, IF
KCNQ1 KCNQ1 Antibody CSB-PA012087KA01HU Human, Mouse, Rat ELISA, WB, IHC
KCNS2 KCNS2 Antibody CSB-PA012096GA01HU Human, Mouse, Rat ELISA, WB, IHC
NCS1 NCS1 Antibody CSB-PA008983ESR1HU Human, Mouse, Rat ELISA, WB, IHC
P2RX4 P2RX4 Antibody CSB-PA017322GA01HU Human, Mouse, Rat ELISA, WB, IHC
P2RX4 P2RX4 Antibody CSB-PA859513LA01HU Human, Mouse, Rat ELISA, WB, IHC
PACSIN3 PACSIN3 Antibody CSB-PA017375GA01HU Human, Mouse, Rat ELISA, WB, IHC
PANX2 PANX2 Antibody CSB-PA839405LA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
POMP POMP Antibody CSB-PA018365GA01HU Human, Mouse, Rat ELISA, WB, IF
PRKCSH PRKCSH Antibody CSB-PA018709GA01HU Human, Mouse, Rat ELISA, WB, IHC
SCNN1B SCNN1B Antibody CSB-PA020849KA01HU Human, Mouse, Rat ELISA, WB, IHC
SCNN1G SCNN1G Antibody CSB-PA020851GA01HU Human, Mouse, Rat ELISA, WB, IHC
SGK3 SGK3 Antibody CSB-PA021191GA01HU Human, Mouse, Rat ELISA, WB, IHC
SLC39A7 SLC39A7 Antibody CSB-PA021636GA01HU Human, Mouse, Rat ELISA, WB, IHC
STIM1 STIM1 Antibody CSB-PA022829GA01HU Human, Mouse, Rat, Zebrafish ELISA, WB, IHC
VDAC1 VDAC1 Antibody CSB-PA025821GA01HU Human, Mouse, Rat ELISA, WB, IHC
VDAC3 VDAC3 Antibody CSB-PA025827GA01HU Human, Mouse, Rat ELISA, WB, IHC
YES1 YES1 Antibody CSB-PA026253GA01HU Human, Mouse, Rat ELISA, WB, IHC
YWHAE YWHAE Antibody CSB-PA026287GA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
YWHAQ YWHAQ Antibody CSB-PA026290GA01HU Human, Mouse, Rat ELISA, WB, IF

Ion channels related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
S100A10 Human Protein S100-A10(S100A10) ELISA kit CSB-EL020623HU serum, plasma, tissue homogenates 0.078 ng/mL
S100A1 Human Soluble protein-100,S-100 ELISA Kit CSB-E08067h serum, plasma, tissue homogenates 0.039 ng/mL
P2RX7 Human P2X purinoceptor 7(P2RX7) ELISA kit CSB-EL017325HU serum, plasma, tissue homogenates, cell lysates 6.25 pg/mL
KCNJ10 Human ATP-sensitive inward rectifier potassium channel 10(KCNJ10) ELISA kit CSB-EL012048HU serum, plasma, tissue homogenates, cell lysates 7 pg/mL
ITPR1 Human Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) ELISA kit CSB-EL011912HU serum, plasma, tissue homogenates, cell lysates 1.56 pg/mL
GRIN2A Human Glutamate [NMDA] receptor subunit epsilon-1(GRIN2A) ELISA kit CSB-EL009912HU serum, plasma, tissue homogenates, cell lysates 3.9 pg/mL
GRIN1 Human Glutamate [NMDA] receptor subunit zeta-1(GRIN1) ELISA kit CSB-EL009911HU serum, plasma, tissue homogenates, cell lysates 31.25 pg/mL
GRIA1 Human Glutamate receptor 1(GRIA1) ELISA kit CSB-EL009898HU serum, plasma, tissue homogenates, cell lysates 5.86 pg/mL
FXYD5 Human FXYD domain-containing ion transport regulator 5(FXYD5) ELISA kit CSB-EL009093HU serum, plasma, tissue homogenates, cell lysates 9.75 pg/mL
EGF Human Epidermal growth factor,EGF ELISA Kit CSB-E08027h serum, plasma, cell culture supernates, tissue homogenates_x005f_x000D_ 0.39 pg/mL
CTNNB1 Human Catenin beta-1 (CTNNB1/CTNNB/OK/SW-cl.35/PRO2286) ELISA kit CSB-E08963h serum, plasma, cell culture supernates, tissue homogenates, cell lysates 3.9 pg/mL
CLDN4 Human Claudin 4 (CLDN4)ELISA Kit CSB-E17961h serum, plasma, tissue homogenates, cell lysates 1.56 pg/mL
CLCA4 Human Calcium-activated chloride channel regulator 4(CLCA4) ELISA kit CSB-EL005477HU serum, plasma, tissue homogenates 3.9 pg/mL
CFTR Human Cystic fibrosis transmembrane conductance regulator(CFTR) ELISA kit CSB-EL005292HU serum, plasma, tissue homogenates, cell lysates 7 pg/mL
CDH5 Human Vascular Endothelial-Cadherin,VE-cad ELISA Kit CSB-E09372h serum, plasma, tissue homogenates 0.98 ng/mL
CAV1 Human Caveolin-1,Cav-1 ELISA KIT CSB-E09682h serum, plasma, tissue homogenates 7.8 pg/mL
ATP6V0A2 Human V-type proton ATPase 116 kDa subunit a isoform 2(ATP6V0A2) ELISA kit CSB-EL002386HU serum, plasma, tissue homogenates 7.81 pg/mL
ATP5PF Human coupling factor 6(CF6)ELISA Kit CSB-E13880h serum, plasma, tissue homogenates 0.78 ng/mL
ATP5MC1 Human ATP synthase lipid-binding protein, mitochondrial(ATP5G1) ELISA kit CSB-EL002359HU serum, plasma, tissue homogenates, cell lysates 5.86 pg/mL
ASPH Human Aspartyl/asparaginyl beta-hydroxylase(ASPH) ELISA kit CSB-EL002226HU serum, plasma, tissue homogenates, cell lysates 1.17 pg/mL
ANXA7 Human Annexin Ⅶ(ANX-Ⅶ) ELISA Kit CSB-E12160h serum, plasma, tissue homogenates, cell lysates 0.31 ng/mL
ANXA6 Human Annexin Ⅵ(ANX-Ⅵ) ELISA Kit CSB-E12159h serum, plasma, tissue homogenates 0.078 ng/mL
ANXA5 Human Annexin Ⅴ,ANX-Ⅴ ELISA Kit CSB-E04882h serum, plasma, cell culture supernates, cell lysates 0.078 ng/mL
ANXA2 Human Annexin Ⅱ(ANX-Ⅱ) ELISA Kit CSB-E12156h serum, urine, saliva, cell lysates 0.098 ng/mL
ANXA1 Human Annexin Ⅰ(ANX-Ⅰ) ELISA Kit CSB-E12155h serum, plasma, tissue homogenates 0.078 ng/mL
SGK1 Human Serine/threonine-protein kinase Sgk1(SGK1) ELISA kit CSB-EL021189HU serum, plasma, tissue homogenates, cell lysates 5.86 pg/mL
SLC40A1 Human Solute carrier family 40 member 1(SLC40A1) ELISA kit CSB-EL021641HU serum, plasma, tissue homogenates, cell lysates 5.8 pg/mL
STIM1 Human Stromal interaction molecule 1(STIM1) ELISA kit CSB-EL022829HU serum, plasma, tissue homogenates 11.7 pg/mL
STX1A Human Syntaxin-1A(STX1A) ELISA kit CSB-EL022895HU serum, tissue homogenates 3.9 pg/mL
TRPV1 Human transient receptor potential cation channel subfamily V member 1 (TrpV1)ELISA Kit CSB-E14198h serum, plasma, tissue homogenates, cell lysates 0.078 ng/mL
TRPV4 Human transient receptor potential cation channel subfamily V member 4 (TrpV4)ELISA Kit CSB-E14199h serum, plasma, tissue homogenates, cell lysates 3.9 pg/mL
TRPV6 Human Transient receptor potential cation channel subfamily V member 6(TRPV6) ELISA kit CSB-EL025098HU serum, plasma, tissue homogenates, cell lysates 5.86 pg/mL
UCP1 Human Mitochondrial brown fat uncoupling protein 1(UCP1) ELISA kit CSB-EL025554HU serum, plasma, tissue homogenates 7.81 pg/mL
YWHAE Human 14-3-3 protein epsilon(YWHAE) ELISA kit CSB-EL026287HU serum, plasma, tissue homogenates, cell lysates 19.5 pg/mL
YWHAH Human 14-3-3 protein eta(YWHAH) ELISA kit CSB-EL026289HU serum, plasma, tissue homogenates 0.156 ng/mL
YWHAQ Human 14-3-3 protein theta(YWHAQ) ELISA kit CSB-EL026290HU serum, plasma, tissue homogenates, cerebrospinal fluid (CSF) 0.11 ng/mL
YWHAZ Human 14-3-3 protein zeta/delta(YWHAZ) ELISA kit CSB-EL026293HU serum, plasma, tissue homogenates 0.156 ng/mL

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