Transmembrane protein series four: ATP-binding cassette transporters

What is ATP-binding cassette transporters?

Transmembrane proteins span the lipid bilayer. According to the number of transmembrane times, it can be divided into one transmembrane protein or multiple transmembrane proteins. Many naturally occurring transmembrane proteins act as channels for specific substances to pass through the biofilm. Some transmembrane proteins can receive or transmit cellular signals. Transmembrane proteins also play an important role in molecular transport.

ATP-binding cassette (ABC) transporters is a transmembrane protein involved in molecular transport.

ATP-binding cassette transporters are the largest known transmembrane protein superfamily. ABC proteins bind and hydrolyze ATP and use energy to drive various molecules across the plasma membrane as well as the endoplasmic reticulum (ER), peroxisome and mitochondrial inner membrane. It is involved in the transport of specific molecules on the lipid membrane and the resistance in all organisms.

ATP-binding cassette (ABC) transporters and disease

ABC gene mutations are associated with the development of certain diseases. These diseases include adrenal white matter dystrophy, cystic fibrosis, retinal degeneration, hypercholesterolemia and cholestasis, neurological diseases, anemia and drug reactions.

Some common single nucleotide polymorphisms in ABCA1 also affect blood lipid levels, atherogenesis, and the severity of coronary heart disease.

ATP-binding cassette (ABC) transporters and drug resistance

MDR refers to the phenomenon that tumor cells have cross-resistance to multiple chemotherapy drugs. This condition is mainly caused by the efflux of cytotoxic drugs mediated by ATP-binding cassette transporter. In the chemotherapy of liver cancer, pancreatic cancer and other tumors, ATP-binding cassette transporter-mediated MDR seriously restricts the efficacy and prognosis of chemotherapy.

ATP-binding cassette (ABC) transporters inhibitors

Evading MDR can inhibit MDR1 synthesis and its activity at the mRNA level, or compete for MDR1 binding sites. In addition, the reversal methods of MDR include immunotherapy reversal, gene reversal, reversal of somatostatin and its analogues, and reversal of Chinese herbal medicine. More information about ABC, you can have a look at this article: A transport machine -- ATP-binding cassette.

In many studies of ABC-related diseases, drug resistance, you may need ABC - related products. CUSABIO has a special transmembrane protein expression system. We could produce 36000+ transmembrane proteins and could also provide marker proteins at mg level for NMR and X-ray studies.

At present, we can produce 133 ABC-related products: 124 antibody products, 5 protein products, 4 ELISA products.

Hot Products

ATP-binding cassette (ABC) transporters related proteins for your research

ATP-binding cassette (ABC) transporters related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
ABCC2 ABCC2 Antibody CSB-PA067303 Human ELISA, WB
ABCC2 ABCC2 Antibody CSB-PA852918LA01HU Human ELISA, IHC, IF
ABCC2 ABCC2 Antibody CSB-PA223592 Human ELISA, IHC
ABCC2 ABCC2 Antibody CSB-PA007024 Human WB, ELISA
ABCC2 ABCC2 Antibody CSB-PA001061GA01HU Human ELISA, WB
ABCC13 ABCC13 Antibody CSB-PA870553 Human ELISA, WB, IHC
ABCC12 ABCC12 Antibody CSB-PA582291 Human, Mouse, Rat ELISA, IHC
ABCC13 ABCC13 Antibody CSB-PA000785 Human WB, IHC, ELISA
ABCC12 ABCC12 Antibody CSB-PA000784 Human WB, ELISA
ABCC1 ABCC1 Antibody CSB-PA997657 Human ELISA, WB, IHC
ABCC10 ABCC10 Antibody CSB-PA112004 Human ELISA, IHC
ABCC10 ABCC10 Antibody CSB-PA003282 Human, Monkey WB, ELISA
ABCB9 ABCB9 Antibody CSB-PA937099 Human ELISA, WB, IHC
ABCB9 ABCB9 Antibody CSB-PA889064LA01HU Human, Mouse ELISA, WB, IF
ABCC1 ABCC1 Antibody CSB-PA984353 Human ELISA, IHC
ABCC1 ABCC1 Antibody CSB-PA579827 Human ELISA, IHC
ABCB9 ABCB9 Antibody CSB-PA001055GA01HU Human, Mouse, Rat ELISA, WB
ABCB8 ABCB8 Antibody CSB-PA868325ESR2HU Human ELISA, IHC
ABCB8 ABCB8 Antibody CSB-PA985454 Human, Mouse, Rat ELISA, WB
ABCB8 ABCB8 Antibody CSB-PA033367 Human, Mouse, Rat ELISA, WB
ABCB7 ABCB7 Antibody CSB-PA001053LA01HU Human ELISA, IHC
ABCB7 ABCB7 Antibody CSB-PA575138 Human ELISA, WB, IHC
ABCB7 ABCB7 Antibody CSB-PA109776 Human, Mouse, Rat ELISA, IHC
ABCB7 ABCB7 Antibody CSB-PA001053GA01HU Human, Mouse, Rat ELISA, WB
ABCB7 ABCB7 Antibody CSB-PA000783 Human WB, IHC, ELISA
ABCB6 ABCB6 Antibody CSB-PA273896 Human, Mouse, Rat ELISA, WB
ABCB6 ABCB6 Antibody CSB-PA976738 Human, Mouse, Rat ELISA, WB, IHC
ABCB6 ABCB6 Antibody CSB-PA001052GA01HU Human, Mouse, Rat ELISA, WB
ABCB5 ABCB5 Antibody CSB-PA643574LA01HU Human ELISA, IHC, IF
ABCB5 ABCB5 Antibody CSB-PA967715 Human, Mouse ELISA, IHC
ABCB5 ABCB5 Antibody CSB-PA181054 Human, Mouse ELISA, IHC
ABCB5 ABCB5 Monoclonal Antibody CSB-MA194827 Human ELISA,WB
ABCB5 ABCB5 Monoclonal Antibody CSB-MA000232 Human ELISA,WB
ABCB11 ABCB11 Antibody CSB-PA447968 Human, Mouse, Rat ELISA, IHC
ABCB11 ABCB11 Antibody CSB-PA437890 Human, Mouse, Rat ELISA, IHC
ABCB10 ABCB10 Antibody CSB-PA697440 Human, Mouse ELISA, WB
ABCB10 ABCB10 Antibody CSB-PA001047GA01HU Human, Mouse, Rat ELISA, WB
ABCB10 ABCB10 Antibody CSB-PA000782 Human WB, IHC, IF, ELISA
ABCB1 ABCB1 Antibody CSB-PA11737A0Rb Human ELISA, IHC, IF
ABCB1 ABCB1 Antibody CSB-PA598314 Human ELISA, IHC
ABCB1 ABCB1 Antibody CSB-PA030050 Human, Mouse, Rat IHC, ELISA
ABCA8 ABCA8 Antibody CSB-PA847031 Human, Mouse ELISA, WB
ABCA8 ABCA8 Antibody CSB-PA000781 Human, Mouse WB, ELISA
ABCA6 ABCA6 Antibody CSB-PA988363 Human ELISA, WB
ABCA6 ABCA6 Antibody CSB-PA000780 Human WB, ELISA
ABCA2 ABCA2 Antibody CSB-PA887172LA01HU Human ELISA, IHC
ABCA2 ABCA2 Antibody CSB-PA949432 Human, Mouse, Rat ELISA, IHC
ABCA2 ABCA2 Antibody CSB-PA001038GA01HU Human, Mouse, Rat ELISA, WB
ABCA13 ABCA13 Antibody CSB-PA007525 Human IF, ELISA
ABCA13 ABCA13 Antibody CSB-PA294593 Human ELISA, IF
ABCB8 ABCB8 Antibody CSB-PA868325ESR1HU Human, Mouse ELISA, WB, IHC
ABCB7 ABCB7 Antibody CSB-PA274413 Human, Mouse, Rat ELISA, IHC
ABCC3 ABCC3 Antibody CSB-PA003281 Human WB, ELISA
ABCC3 ABCC3 Antibody CSB-PA914467 Human, Mouse ELISA, IHC
ABCC3 ABCC3 Antibody CSB-PA105454 Human ELISA, WB
ABCC3 ABCC3 Antibody CSB-PA001062LA01HU Human ELISA, IF
ABCC5 ABCC5 Antibody CSB-PA951195 Human, Mouse, Rat ELISA, WB, IHC
ABCC5 ABCC5 Antibody CSB-PA001064LA01HU Human ELISA, IHC, IF
ABCD1 ABCD1 Antibody CSB-PA008163 Human WB, ELISA
ABCD1 ABCD1 Antibody CSB-PA001068GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCD1 ABCD1 Antibody CSB-PA214656 Human ELISA, WB
ABCD1 ABCD1 Antibody CSB-PA001068LA01HU Human ELISA, IHC
ABCD2 ABCD2 Antibody CSB-PA909687 Human, Mouse, Rat ELISA, IHC
ABCD2 ABCD2 Antibody CSB-PA866202LA01HU Human ELISA, IHC
ABCD4 ABCD4 Antibody CSB-PA000786 Human, Mouse WB, IHC, ELISA
ABCD4 ABCD4 Antibody CSB-PA047241 Human, Mouse ELISA, WB
ABCD4 ABCD4 Antibody CSB-PA039868 Human, Mouse ELISA, WB
ABCD4 ABCD4 Antibody CSB-PA970746 Human ELISA, WB
ABCD4 ABCD4 Antibody CSB-PA001075LA01HU Human ELISA, IHC
ABCE1 ABCE1 Antibody CSB-PA001076GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCE1 ABCE1 Antibody CSB-PA591967 Human, Mouse ELISA, WB
ABCE1 ABCE1 Antibody CSB-PA802152 Human, Mouse ELISA, WB
ABCE1 ABCE1 Antibody CSB-PA001076ESR2HU Human ELISA, WB, IHC
ABCF1 ABCF1 Antibody CSB-PA008299 Human, Mouse, Rat WB, ELISA
ABCF1 ABCF1 Antibody CSB-PA001077GA01HU Human, Mouse, Rat ELISA, WB
ABCF1 ABCF1 Antibody CSB-PA261772 Human, Mouse, Rat ELISA, IHC
ABCF1 ABCF1 Antibody CSB-PA146685 Human, Mouse, Rat ELISA, IHC
ABCF1 ABCF1 Antibody CSB-PA554269 Human, Mouse, Rat ELISA, WB
ABCF2 ABCF2 Antibody CSB-PA000787 Human, Mouse, Rat WB, ELISA
ABCF2 ABCF2 Antibody CSB-PA001078GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCF2 ABCF2 Antibody CSB-PA960487 Human, Mouse ELISA, IHC
ABCF2 ABCF2 Antibody CSB-PA931399 Human, Mouse ELISA, IHC
ABCF2 ABCF2 Antibody CSB-PA995376 Human ELISA, WB
ABCF2 ABCF2 Antibody CSB-PA871400ESR2HU Human ELISA, WB, IHC
ABCF3 ABCF3 Antibody CSB-PA595084 Human, Mouse, Rat ELISA, IHC
ABCF3 ABCF3 Antibody CSB-PA781903 Human, Mouse, Rat ELISA, IHC
ABCF3 ABCF3 Antibody CSB-PA889115LA01HU Human ELISA, IHC
ABCG1 ABCG1 Antibody CSB-PA004679 Human, Mouse, Rat WB, ELISA
ABCG1 ABCG1 Antibody CSB-PA001080GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCG1 ABCG1 Antibody CSB-PA127583 Human ELISA, WB, IHC
ABCG1 ABCG1 Antibody CSB-PA139278 Human ELISA, WB, IHC
ABCG1 ABCG1 Antibody CSB-PA001080LA01HU Human ELISA, IHC
ABCG2 ABCG2 Antibody CSB-PA006120 Human WB, ELISA
ABCG2 ABCG2 Antibody CSB-PA000788 Human WB, IHC, ELISA
ABCG2 ABCG2 Antibody CSB-PA001081GA01HU Human, Mouse, Rat ELISA, WB
ABCG2 ABCG2 Antibody CSB-PA988836 Human ELISA, WB, IHC
ABCG2 ABCG2 Antibody CSB-PA440339 Human ELISA, WB, IHC
ABCG2 ABCG2 Antibody CSB-PA570300 Human ELISA, WB
ABCG2 ABCG2 Antibody CSB-PA891568LA01HU Human ELISA, IF
ABCG4 ABCG4 Antibody CSB-PA001082GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCG4 ABCG4 Antibody CSB-PA040368 Human, Mouse ELISA, WB
ABCG5 ABCG5 Antibody CSB-PA935474 Human ELISA, IHC
ABCG5 ABCG5 Antibody CSB-PA863956LA01HU Human ELISA, WB, IHC, IF

ATP-binding cassette (ABC) transporters related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
ABCG2 Human ATP-binding cassette transporter G2,ABCG2 ELISA Kit CSB-E11251h serum, plasma, cell lysates, cell culture supernates 0.039 ng/mL
ABCC5 Human Soluble Mesothelin Related Peptide(SMRP)ELISA Kit CSB-E13725h serum, plasma, tissue homogenates, cell lysates 0.078 pmol/mL
ABCB1 Human permeability glycoprotein,P-gp/ABCB1 ELISA Kit CSB-E11709h serum, plasma, ascitic fluid, tissue homogenates 0.78 ng/mL

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