Transmembrane protein series four: ATP-binding cassette transporters

What is ATP-binding cassette transporters?

Transmembrane proteins span the lipid bilayer. According to the number of transmembrane times, it can be divided into one transmembrane protein or multiple transmembrane proteins. Many naturally occurring transmembrane proteins act as channels for specific substances to pass through the biofilm. Some transmembrane proteins can receive or transmit cellular signals. Transmembrane proteins also play an important role in molecular transport.

ATP-binding cassette (ABC) transporters is a transmembrane protein involved in molecular transport.

ATP-binding cassette transporters are the largest known transmembrane protein superfamily. ABC proteins bind and hydrolyze ATP and use energy to drive various molecules across the plasma membrane as well as the endoplasmic reticulum (ER), peroxisome and mitochondrial inner membrane. It is involved in the transport of specific molecules on the lipid membrane and the resistance in all organisms.

ATP-binding cassette (ABC) transporters and disease

ABC gene mutations are associated with the development of certain diseases. These diseases include adrenal white matter dystrophy, cystic fibrosis, retinal degeneration, hypercholesterolemia and cholestasis, neurological diseases, anemia and drug reactions.

Some common single nucleotide polymorphisms in ABCA1 also affect blood lipid levels, atherogenesis, and the severity of coronary heart disease.

ATP-binding cassette (ABC) transporters and drug resistance

MDR refers to the phenomenon that tumor cells have cross-resistance to multiple chemotherapy drugs. This condition is mainly caused by the efflux of cytotoxic drugs mediated by ATP-binding cassette transporter. In the chemotherapy of liver cancer, pancreatic cancer and other tumors, ATP-binding cassette transporter-mediated MDR seriously restricts the efficacy and prognosis of chemotherapy.

ATP-binding cassette (ABC) transporters inhibitors

Evading MDR can inhibit MDR1 synthesis and its activity at the mRNA level, or compete for MDR1 binding sites. In addition, the reversal methods of MDR include immunotherapy reversal, gene reversal, reversal of somatostatin and its analogues, and reversal of Chinese herbal medicine. More information about ABC, you can have a look at this article: A transport machine -- ATP-binding cassette.

In many studies of ABC-related diseases, drug resistance, you may need ABC - related products. CUSABIO has a special transmembrane protein expression system. We could produce 36000+ transmembrane proteins and could also provide marker proteins at mg level for NMR and X-ray studies.

At present, we can produce 133 ABC-related products: 124 antibody products, 5 protein products, 4 ELISA products.

Hot Products

ATP-binding cassette (ABC) transporters related proteins for your research

ATP-binding cassette (ABC) transporters related antibodies for your research

Target Product Name Code Species Reactivity Tested Applications
ABCB10 ABCB10 Antibody CSB-PA001047GA01HU Human, Mouse, Rat ELISA, WB
ABCA9 ABCA9 Antibody CSB-PA812864LA01HU Human ELISA, IF
ABCB1 ABCB1 Antibody CSB-PA11737A0Rb Human ELISA, WB, IHC, IF
ABCA3 ABCA3 Antibody CSB-PA859942ESR1HU Human ELISA, IHC
ABCA5 ABCA5 Antibody CSB-PA845163LA01HU Human ELISA, IHC
ABCA2 ABCA2 Antibody CSB-PA887172LA01HU Human ELISA, IHC
ABCA12 ABCA12 Antibody CSB-PA774804LA01HU Human ELISA, IF
ABCA2 ABCA2 Antibody CSB-PA001038GA01HU Human, Mouse, Rat ELISA, WB
ABCB4 ABCB4 Antibody CSB-PA001050LA01HU Human ELISA, IHC, IF
ABCB5 ABCB5 Antibody CSB-PA643574LA01HU Human ELISA, IHC, IF
ABCB6 ABCB6 Antibody CSB-PA001052GA01HU Human, Mouse, Rat ELISA, WB
ABCB7 ABCB7 Antibody CSB-PA001053GA01HU Human, Mouse, Rat ELISA, WB
ABCB7 ABCB7 Antibody CSB-PA001053LA01HU Human ELISA, IHC
ABCB8 ABCB8 Antibody CSB-PA868325ESR1HU Human, Mouse ELISA, WB, IHC
ABCB8 ABCB8 Antibody CSB-PA868325ESR2HU Human ELISA, IHC
ABCB9 ABCB9 Antibody CSB-PA001055GA01HU Human, Mouse, Rat ELISA, WB
ABCB9 ABCB9 Antibody CSB-PA889064LA01HU Human, Mouse ELISA, WB, IF
ABCC11 ABCC11 Antibody CSB-PA846641ESR1HU Human ELISA, IHC
ABCC2 ABCC2 Antibody CSB-PA001061GA01HU Human ELISA, WB
ABCC2 ABCC2 Antibody CSB-PA852918LA01HU Human ELISA, IHC, IF
ABCC3 ABCC3 Antibody CSB-PA001062LA01HU Human ELISA, IF
ABCC4 ABCC4 Antibody CSB-PA001063KA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCC4 ABCC4 Antibody CSB-PA001063LA01HU Human ELISA, IF
ABCC5 ABCC5 Antibody CSB-PA001064LA01HU Human ELISA, IHC, IF
ABCC6 ABCC6 Antibody CSB-PA001065LA01HU Human ELISA, IF
ABCC8 ABCC8 Antibody CSB-PA22439A0Rb Human ELISA, IHC, IF
ABCC9 ABCC9 Antibody CSB-PA001067LA01HU Human ELISA, IHC, IF
ABCD1 ABCD1 Antibody CSB-PA001068GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCD1 ABCD1 Antibody CSB-PA001068LA01HU Human ELISA, IHC
ABCD2 ABCD2 Antibody CSB-PA866202LA01HU Human ELISA, IHC
ABCD4 ABCD4 Antibody CSB-PA001075LA01HU Human ELISA, IHC
ABCE1 ABCE1 Antibody CSB-PA001076GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCE1 ABCE1 Antibody CSB-PA001076ESR2HU Human ELISA, WB, IHC
ABCF1 ABCF1 Antibody CSB-PA001077GA01HU Human, Mouse, Rat ELISA, WB
ABCF2 ABCF2 Antibody CSB-PA001078GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCF2 ABCF2 Antibody CSB-PA871400ESR2HU Human ELISA, WB, IHC
ABCF3 ABCF3 Antibody CSB-PA889115LA01HU Human ELISA, IHC
ABCG1 ABCG1 Antibody CSB-PA001080GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCG1 ABCG1 Antibody CSB-PA001080LA01HU Human ELISA, IHC
ABCG2 ABCG2 Antibody CSB-PA001081GA01HU Human, Mouse, Rat ELISA, WB
ABCG2 ABCG2 Antibody CSB-PA891568LA01HU Human ELISA, IF
ABCG4 ABCG4 Antibody CSB-PA001082GA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCG5 ABCG5 Antibody CSB-PA863956LA01HU Human ELISA, WB, IHC, IF
ABCG8 ABCG8 Antibody CSB-PA001084KA01HU Human, Mouse, Rat ELISA, WB, IHC
ABCG8 ABCG8 Antibody CSB-PA875651LA01HU Human, Mouse ELISA, WB, IHC, IF
TAP1 TAP1 Antibody CSB-PA023120GA01HU Human, Mouse, Rat ELISA, WB, IHC, IF
TAP1 TAP1 Antibody CSB-PA023120ESR1HU Human ELISA, IHC
TAP2 TAP2 Antibody CSB-PA22539A0Rb Human ELISA, IHC
TAP2 TAP2 Antibody CSB-PA023121KA01HU Human, Mouse, Rat ELISA, WB, IHC

ATP-binding cassette (ABC) transporters related ELISA kits for your research

Target Product Name Code Sample Type Sensitivity
ABCB1 Human permeability glycoprotein,P-gp/ABCB1 ELISA Kit CSB-E11709h serum, plasma, ascitic fluid, tissue homogenates 0.78 ng/mL
ABCC5 Human Soluble Mesothelin Related Peptide(SMRP)ELISA Kit CSB-E13725h serum, plasma, tissue homogenates, cell lysates 0.078 pmol/mL
ABCG2 Human ATP-binding cassette transporter G2,ABCG2 ELISA Kit CSB-E11251h serum, plasma, cell lysates, cell culture supernates 0.039 ng/mL
CFTR Human Cystic fibrosis transmembrane conductance regulator(CFTR) ELISA kit CSB-EL005292HU serum, plasma, tissue homogenates, cell lysates 7 pg/mL

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