Chemokine receptors are G protein-coupled receptors and consists of approximately 350 amino acids, and figure 1 shows a schematic presentation of its structure. The chemokine receptors are all seven-transmembrane (7TM) receptors with seven helical membrane-spanning regions that are found predominantly on the surface of leukocytes, making it one of the rhodopsin-like receptors. Recently, the chemokine receptors have come to attract more attention than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states.
Figure 1. Schematic presentation of the chemokine receptor structure
Chemokine receptor consists of approximately 350 amino acids and a class of GTP-protein-coupled transmembrane receptors (GPCRs) that mediate the function of chemokines and are normally expressed on cell membranes such as immune cells and endothelial cells. There are two families of heptahelical surface molecules that bind to chemokines: conventional chemokine receptors (cCKRs) and atypical chemokine receptors (ACKRs).
Chemokine‐bound cCKRs typically transduce signals through pertussis toxin‐sensitive Gαi G‐proteins and β‐arrestins, ultimately leading to cell migration, adhesion and/or a variety of other biological responses. There are currently 18 cCKRs named according to the predominant type of chemokine they bind (i.e., CC, CXC, CX3C, or XC), followed by the letter R (denoting 'receptor'), and then a number reflecting the order of their discovery. Atypical chemokine receptors, of which there are four, are structurally related to cCKRs but do not couple to many, if any, of the signal transduction pathways activated by cCKRs. These members are as follows:
If you want to obtain more information about chemokine receptors, you can click to read the article entilted Chemokine Receptors-One Kind of Powerful Seven Transmembrane Spanning G Protein-coupled Receptor.
At present, we can provide a series of chemokine receptors related products, involving proteins, antibodies and ELISA kits. Among the three types of products, CUSABIO chemokine receptors proteins are more popular than others with the following features:
Recombinant Human Atypical chemokine receptor 2(ACKR2) (CSB-CF004618HU)
Recombinant Human C-C chemokine receptor type 2(CCR2) (CSB-CF004841HU)
Target | Product Name | Code | Expression System |
---|---|---|---|
ACKR1 | Recombinant Human Atypical chemokine receptor 1(ACKR1) | CSB-CF624105HU | in vitro E.coli expression system |
ACKR2 | Recombinant Human Atypical chemokine receptor 2(ACKR2) | CSB-CF004618HU | in vitro E.coli expression system |
ACKR3 | Recombinant Human Atypical chemokine receptor 3(ACKR3) | CSB-CF006257HU | in vitro E.coli expression system |
ACKR4 | Recombinant Human Atypical chemokine receptor 4(ACKR4) | CSB-CF865095HU | in vitro E.coli expression system |
CCR1 | Recombinant Human C-C chemokine receptor type 1(CCR1) | CSB-CF004839HU | in vitro E.coli expression system |
CCR10 | Recombinant Human C-C chemokine receptor type 10(CCR10) | CSB-CF004840HU | in vitro E.coli expression system |
CCR2 | Recombinant Human C-C chemokine receptor type 2(CCR2) | CSB-CF004841HU | in vitro E.coli expression system |
CCR2 | Recombinant Mouse C-C chemokine receptor type 2(Ccr2) | CSB-CF004841MO | in vitro E.coli expression system |
CCR2 | Recombinant Macaca mulatta C-C chemokine receptor type 2(CCR2) | CSB-CF004841MOW | in vitro E.coli expression system |
CCR3 | Recombinant Human C-C chemokine receptor type 3(CCR3) | CSB-CF004842HU | in vitro E.coli expression system |
CCR4 | Recombinant Human C-C chemokine receptor type 4(CCR4) | CSB-CF004843HU | in vitro E.coli expression system |
CCR5 | Recombinant Human C-C chemokine receptor type 5(CCR5) | CSB-CF004844HU | in vitro E.coli expression system |
CCR6 | Recombinant Human C-C chemokine receptor type 6(CCR6) | CSB-CF004845HU | in vitro E.coli expression system |
CCR7 | Recombinant Human C-C chemokine receptor type 7(CCR7) | CSB-CF004846HU | in vitro E.coli expression system |
Ccr8 | Recombinant Mouse C-C chemokine receptor type 8(Ccr8) | CSB-CF004847MO | in vitro E.coli expression system |
CCR8 | Recombinant Human C-C chemokine receptor type 8(CCR8) | CSB-CF004847HU | in vitro E.coli expression system |
CCR9 | Recombinant Human C-C chemokine receptor type 9(CCR9) | CSB-CF004848HU | in vitro E.coli expression system |
CCRL2 | Recombinant Human C-C chemokine receptor-like 2(CCRL2) | CSB-CF004852HU | in vitro E.coli expression system |
CX3CR1 | Recombinant Human CX3C chemokine receptor 1(CX3CR1) | CSB-CF006236HU | in vitro E.coli expression system |
CXCR1 | Recombinant Human C-X-C chemokine receptor type 1(CXCR1) | CSB-CF011672HU | in vitro E.coli expression system |
CXCR2 | Recombinant Human C-X-C chemokine receptor type 2(CXCR2) | CSB-CF011673HU | in vitro E.coli expression system |
CXCR3 | Recombinant Human C-X-C chemokine receptor type 3(CXCR3) | CSB-CF006253HU | in vitro E.coli expression system |
CXCR3 | Recombinant Human C-X-C chemokine receptor type 3(CXCR3) | CSB-CF006253HUb0 | in vitro E.coli expression system |
CXCR4 | Recombinant Human C-X-C chemokine receptor type 4(CXCR4) | CSB-CF006254HU | in vitro E.coli expression system |
CXCR4 | Recombinant Human C-X-C chemokine receptor type 4(CXCR4) | CSB-CF006254HUa0 | in vitro E.coli expression system |
CXCR5 | Recombinant Human C-X-C chemokine receptor type 5(CXCR5) | CSB-CF006255HU | in vitro E.coli expression system |
CXCR6 | Recombinant Human C-X-C chemokine receptor type 6(CXCR6) | CSB-CF006256HU | in vitro E.coli expression system |
XCR1 | Recombinant Human Chemokine XC receptor 1(XCR1) | CSB-CF026188HU | in vitro E.coli expression system |
Target | Product Name | Code | Species Reactivity | Tested Applications |
---|---|---|---|---|
ACKR1 | ACKR2 Antibody | CSB-PA001619 | Human | ELISA, WB, IHC, IF |
CCR1 | CCR1 Antibody | CSB-PA004839LA01HU | Human | ELISA, IHC, IF |
CCR10 | CCR10 Antibody | CSB-PA004840LA01HU | Human | ELISA, WB, IHC, IF |
CCR2 | CCR2 Antibody | CSB-PA004841GA01HU | Human | ELISA, WB |
CCR2 | CCR2 Antibody | CSB-PA004841LA01HU | Human | ELISA, IF |
CCR3 | CCR3 Antibody | CSB-PA004842LA01HU | Human, Mouse | ELISA, WB, IHC, IF |
CCR5 | CCR5 Antibody | CSB-PA004844GA01HU | Human, Mouse, Rat | ELISA, WB |
CCR6 | CCR6 Antibody | CSB-PA004845EA01HU | Human | ELISA, WB |
CCR8 | CCR8 Antibody | CSB-PA091770 | Human | ELISA, WB, IHC |
CCR8 | CCR8 Antibody | CSB-PA172806 | Human | ELISA, WB, IHC |
CCR9 | CCR9 Antibody | CSB-PA035070 | Human, Mouse | ELISA, IHC |
CCR9 | CCR9 Antibody | CSB-PA293047 | Human, Mouse | ELISA, IHC |
CCRL2 | CCRL2 Antibody | CSB-PA004852LA01HU | Human | ELISA, WB, IHC |
CX3CR1 | CX3CR1 Antibody | CSB-PA006236GA01HU | Human, Mouse, Rat | ELISA, WB |
CX3CR1 | CX3CR1 Antibody | CSB-PA006236LA01HU | Human | ELISA, IHC, IF |
CXCR2 | Phospho-CXCR2 (S347) Antibody | CSB-PA009566 | Human, Mouse | ELISA, WB, IHC, IF |
CXCR2 | CXCR2 Antibody | CSB-PA011673GA01HU | Human | ELISA, WB, IF |
CXCR2 | CXCR2 Antibody | CSB-PA011673HA01HU | Human | ELISA, IHC, IF |
CXCR3 | CXCR3 Antibody | CSB-PA006253LA01HU | Human | ELISA, WB, IHC, IF |
CXCR4 | Phospho-CXCR4 (S339) Antibody | CSB-PA060127 | Human, Mouse, Rat, Monkey | ELISA, WB, IHC, IF |
CXCR4 | CXCR4 Antibody | CSB-PA006254GA01HU | Human, Mouse, Rat | ELISA, WB |
CXCR4 | CXCR4 Antibody | CSB-PA006254YA01HU | Human, Mouse | ELISA, WB, IHC, IF |
CXCR5 | CXCR5 Antibody | CSB-PA006255LA01HU | Human | ELISA, IHC, IF |
CXCR6 | CXCR6 Antibody | CSB-PA224134 | Human, Mouse | ELISA, WB, IHC |
CXCR6 | CXCR6 Antibody | CSB-PA188638 | Human, Mouse | ELISA, WB, IHC |
Target | Product Name | Code | Sample Type | Sensitivity |
---|---|---|---|---|
CCR2 | Human CC-Chemokine Receptor 2,CCR2 ELISA Kit | CSB-E14200h | serum, plasma, tissue homogenates, cerebrospinal fluid (CSF) | 5.86 pg/mL |
CCR2 | Mouse C-C chemokine receptor type 2(CCR2) ELISA kit | CSB-EL004841MO | serum, plasma, tissue homogenates | 3.9 pg/mL |
CX3CR1 | Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit | CSB-E09942h | serum, plasma, tissue homogenates | 7.8 pg/mL |
Aquaporin
Ion Channels
G protein-Coupled Receptor
ATP-binding Cassette
Human Leukocyte Antigen