- Full-length transmembrane protein
- Seven-times transmembrane
- High Purity (>85%)
- Active Verification
Chemokine receptors are G protein-coupled receptors and consists of approximately 350 amino acids. The chemokine receptors are all seven-transmembrane (7TM) receptors with seven helical membrane-spanning regions that are found predominantly on the surface of leukocytes, making it one of the rhodopsin-like receptors. Recently, the chemokine receptors have come to attract more attention than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states.
Chemokine receptor consists of approximately 350 amino acids and a class of GTP-protein-coupled transmembrane receptors (GPCRs) that mediate the function of chemokines and are normally expressed on cell membranes such as immune cells and endothelial cells.
As mentioned before, Chemokine receptors are cytokine receptors expressed on the cell surface as 7-transmembrane proteins that interact with a type of cytokine called a chemokine. The seven transmembrane regions divide the protein into several sections, including extracellular free N-terminals, three extracellular loops, three intracellular loops, and a C-terminus containing serine and threonine residues that act as phosphorylation sites during receptor regulation.
If you want to obtain more information about chemokine receptors, you can click here to read the article entilted Chemokine Receptors – One Kind of Powerful Seven Transmembrane Spanning G Protein-coupled Receptor.
At present, we can provide a series of chemokine receptors related products, involving proteins, antibodies and ELISA kits. Among the three types of products, CUSABIO chemokine receptors proteins are more popular than others with the following features:
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