Transmembrane protein series six: Chemokine receptors

What are Chemokine receptors?

Chemokine receptors are G protein-coupled receptors and consists of approximately 350 amino acids, and figure 1 shows a schematic presentation of its structure. The chemokine receptors are all seven-transmembrane (7TM) receptors with seven helical membrane-spanning regions that are found predominantly on the surface of leukocytes, making it one of the rhodopsin-like receptors. Recently, the chemokine receptors have come to attract more attention than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states.

Figure 1. Schematic presentation of the chemokine receptor structure

What are the function and types of chemokine receptors?

Chemokine receptor consists of approximately 350 amino acids and a class of GTP-protein-coupled transmembrane receptors (GPCRs) that mediate the function of chemokines and are normally expressed on cell membranes such as immune cells and endothelial cells. There are two families of heptahelical surface molecules that bind to chemokines: conventional chemokine receptors (cCKRs) and atypical chemokine receptors (ACKRs).

Chemokine‐bound cCKRs typically transduce signals through pertussis toxin‐sensitive Gαi G‐proteins and β‐arrestins, ultimately leading to cell migration, adhesion and/or a variety of other biological responses. There are currently 18 cCKRs named according to the predominant type of chemokine they bind (i.e., CC, CXC, CX3C, or XC), followed by the letter R (denoting 'receptor'), and then a number reflecting the order of their discovery. Atypical chemokine receptors, of which there are four, are structurally related to cCKRs but do not couple to many, if any, of the signal transduction pathways activated by cCKRs. These members are as follows:

● Conventional chemokine receptors (cCKRs)

● Atypical chemokine receptors (ACKRs)

The features of CUSABIO chemokine receptors proteins

At present, we can provide a series of chemokine receptors related products, involving proteins, antibodies and ELISA kits. Among the three types of products, CUSABIO chemokine receptors proteins are more popular than others with the following features:

• Full-length transmembrane protein
• Seven-times transmembrane
• High Purity (>85%)
• Active Verification