Antigen processing and presentation involve two main pathway: MHC Ⅰ pathway and MHC Ⅱ pathway. Antigen presenting cells are important components of antigen presenting signaling pathway.
Antigen presenting cells are a kind of immune cells, whose main function is to absorb, process and present the processed antigen to T and B lymphocytes. APC can be divided into professional APC and non-professional APC. Professional APCs include mononuclear-macrophages, dendritic cells, endothelial cells, and B cells. It is characterized by the expression of MHC class II molecules; non-professional APCs usually do not express MHC class II molecules.
In the MHC Ⅰ pathway, intracellular synthetic endogenous antigens (such as tumor antigens and viral protein antigens, etc.) can be degraded into small molecular polypeptides by the proteasome in the cytoplasm.
Small molecule polypeptides bind to heat shock protein 70/90 in the cytoplasm and are then transferred into the endoplasmic reticulum via TAP and modified into antigenic peptides. MHC-I molecules are synthesized in the endoplasmic reticulum and bind to antigenic peptides to form complexes. The complex is transferred into the golgi apparatus and then transported to the APC surface by secretory vesicles for binding recognition by the corresponding CD8+T cells.
In the MHC II pathway, the exogenous antigen is taken up by the APC by phagocytosis, and is decomposed into a small molecule polypeptide in the acidic environment of the endosome. The immunogenic small molecule polypeptide is called antigen. Peptide. On the other hand, MHC class II molecules are synthesized in the endoplasmic reticulum. The MHC class II molecule binds to the antigen peptide to form a complex, which is transported to the surface of the APC membrane by the Golgi apparatus and presented to CD4+ T cells with specific TCR for recognition.
|IFI30||IFI30 Antibody||IFI30 Protein||IFI30 cDNA||IFI30 ELISA Kit|
|IFNG||IFNG Antibody||IFNG Protein||IFNG cDNA||IFNG ELISA Kit|
|KIR2DL1||KIR2DL1 Antibody||KIR2DL1 Protein||KIR2DL1 cDNA||KIR2DL1 ELISA Kit|
|KIR2DL2||KIR2DL2 Antibody||KIR2DL2 Protein||KIR2DL2 cDNA||KIR2DL2 ELISA Kit|
|KIR2DL3||KIR2DL3 Antibody||KIR2DL3 Protein||KIR2DL3 cDNA||KIR2DL3 ELISA Kit|
|KIR2DL4||KIR2DL4 Antibody||KIR2DL4 Protein||KIR2DL4 cDNA||KIR2DL4 ELISA Kit|
|KIR2DL5A||KIR2DL5A Antibody||KIR2DL5A Protein||KIR2DL5A cDNA||KIR2DL5A ELISA Kit|
|KIR2DS1||KIR2DS1 Antibody||KIR2DS1 Protein||KIR2DS1 cDNA||KIR2DS1 ELISA Kit|
|KIR2DS2||KIR2DS2 Antibody||KIR2DS2 Protein||KIR2DS2 cDNA||KIR2DS2 ELISA Kit|
|KIR2DS3||KIR2DS3 Antibody||KIR2DS3 Protein||KIR2DS3 cDNA||KIR2DS3 ELISA Kit|
|KIR2DS4||KIR2DS4 Antibody||KIR2DS4 Protein||KIR2DS4 cDNA||KIR2DS4 ELISA Kit|
|KIR2DS5||KIR2DS5 Antibody||KIR2DS5 Protein||KIR2DS5 cDNA||KIR2DS5 ELISA Kit|
|KIR3DL1||KIR3DL1 Antibody||KIR3DL1 Protein||KIR3DL1 cDNA||KIR3DL1 ELISA Kit|
|KIR3DL2||KIR3DL2 Antibody||KIR3DL2 Protein||KIR3DL2 cDNA||KIR3DL2 ELISA Kit|
|KIR3DL3||KIR3DL3 Antibody||KIR3DL3 Protein||KIR3DL3 cDNA||KIR3DL3 ELISA Kit|
|KLRC1||KLRC1 Antibody||KLRC1 Protein||KLRC1 cDNA||KLRC1 ELISA Kit|
|KLRC2||KLRC2 Antibody||KLRC2 Protein||KLRC2 cDNA||KLRC2 ELISA Kit|
|KLRC3||KLRC3 Antibody||KLRC3 Protein||KLRC3 cDNA||KLRC3 ELISA Kit|
|KLRC4||KLRC4 Antibody||KLRC4 Protein||KLRC4 cDNA||KLRC4 ELISA Kit|
|KLRD1||KLRD1 Antibody||KLRD1 Protein||KLRD1 cDNA||KLRD1 ELISA Kit|