ACKR3

ACKR3, also known as atypical chemokine receptor 3 or CXCR7, is a G-protein coupled receptor that serves as a scavenger receptor for chemokines like CXCL12 and CXCL11. It modulates CXCR4 functions by forming heterodimers and influences various signaling pathways, including β-arrestin and Gαi. ACKR3 is involved in normal development and physiology, particularly in cardiac development, neuronal migration, and renal function. It is also associated with diseases such as cardiovascular defects, neurological disorders, and renal carcinoma. Research on ACKR3 has led to potential therapeutic targets for drug development, focusing on modulating its signaling pathways and ligand interactions.