ADGRE1

ADGRE1 is a special type of receptor that belongs to the G protein-coupled receptor 2 family, particularly within the adhesion G protein-coupled receptor (ADGR) group. This receptor is crucial for how cells stick together and may also play a part in how immune cells communicate with each other. Studies suggest that ADGRE1 is involved in the formation of a specific type of immune cell called regulatory T cells, or Tregs. ADGRE1 is not just important for many biological activities, but it also has a key function in our immune system, which is shown by its presence in cells like monocytes and macrophages in mammals. Interestingly, in African domestic dogs, ADGRE1 is associated with genetic resistance to malaria parasite infection. This resistance might be due to the increased activity of genes involved in the type I interferon pathway, which helps the dogs fight off the malaria parasite more effectively.