AKAP8L is a protein in humans that is encoded by AKAP8L gene. Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing.
The following AKAP8L reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
AKAP8L Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA001531GA01HU | AKAP8L Antibody | Human,Mouse,Rat | ELISA |
CSB-PA892152ESR1HU | AKAP8L Antibody | Human | ELISA, IHC |
CSB-PA547116 | AKAP8L Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA550074 | AKAP8L Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA611485 | AKAP8L Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA697958 | AKAP8L Antibody | Human,Mouse | ELISA,WB,IHC |
AKAP8L Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP889923MO CSB-EP889923MO CSB-BP889923MO CSB-MP889923MO CSB-EP889923MO-B |
Recombinant Mouse A-kinase anchor protein 8-like (Akap8l) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKAP8L Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP892152HU CSB-EP892152HU CSB-BP892152HU CSB-MP892152HU CSB-EP892152HU-B |
Recombinant Human A-kinase anchor protein 8-like (AKAP8L) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |