ALPK1

ALPK1, also known as α-kinase 1, and by its aliases LAK and ROSAH, is an atypical serine/threonine protein kinase that lacks sequence homology with conventional protein kinases. ALPK1 is expressed in a variety of tissues, including bone marrow and skin.
The mechanism of action of ALPK1 involves the recognition and specific binding to ADP-heptose, a precursor sugar molecule in the synthesis of bacterial lipopolysaccharide (LPS), which subsequently activates the NF-κB pathway to mediate innate immune inflammatory responses.
As a pattern recognition receptor (PRR), ALPK1 plays a crucial role in the innate immune response, particularly in the recognition of pathogen-associated molecular patterns (PAMPs) and the activation of host immune responses. The activation of ALPK1 can induce antitumor immunity, and it holds potential application value in the field of tumor immunotherapy.