Rho guanine nucleotide exchange factor 1 is a protein in humans that is encoded by ARHGEF1 gene. Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
The following ARHGEF1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ARHGEF1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002040GA01HU | ARHGEF1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA791509 | ARHGEF1 Antibody | Human | ELISA,WB |
CSB-PA003977 | ARHGEF1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA123263 | ARHGEF1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA255560 | ARHGEF1 Antibody | Human,Mouse,Rat | ELISA,IHC |
ARHGEF1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP726740MO CSB-EP726740MO CSB-BP726740MO CSB-MP726740MO CSB-EP726740MO-B |
Recombinant Mouse Rho guanine nucleotide exchange factor 1 (Arhgef1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARHGEF1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP856434HU CSB-EP856434HU CSB-BP856434HU CSB-MP856434HU CSB-EP856434HU-B |
Recombinant Human Rho guanine nucleotide exchange factor 1 (ARHGEF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |