ARHGEF1

Rho guanine nucleotide exchange factor 1 is a protein in humans that is encoded by ARHGEF1 gene. Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

ARHGEF1 Antibodies

ARHGEF1 Antibodies for Homo sapiens (Human)

ARHGEF1 Proteins

ARHGEF1 Proteins for Mus musculus (Mouse)

ARHGEF1 Proteins for Homo sapiens (Human)

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