ATG4C Research Reagents

Cysteine protease ATG4C is a protein in humans that is encoded by ATG4C gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

The following ATG4C reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ATG4C Antibodies

ATG4C Antibodies for Homo sapiens (Human)

ATG4C Proteins

ATG4C Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

ATG4C Proteins for Xenopus laevis (African clawed frog)

ATG4C Proteins for Mus musculus (Mouse)

ATG4C Proteins for Homo sapiens (Human)

ATG4C Background

Cysteine protease ATG4C is a protein in humans that is encoded by the ATG4C gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. It is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). ATG4C cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. It has also an activity of the delipidating enzyme for the PE-conjugated forms.

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