AURKA

AURKA, Aurora kinase A, aliases include IAK, Ark1, Ayk1, IAK1, Stk6, AIRK1, ARK-1, and Aurora-A. It is a serine/threonine kinase originally discovered in Drosophila, where mutations lead to inhibition of centromere segregation, which in turn affects the normal progression of mitosis.AURKA plays an important regulatory role in the process of mitosis, especially the initiation of centromere maturation and cytoplasmic division. AURKA plays an important role in the regulation of cellular mitosis, especially in centriole maturation, mitosis initiation, bipolar spindle formation and cytoplasmic division.The biological significance of AURKA is mainly reflected in its regulatory effects on tumour cell proliferation, genomic instability, cell survival, invasion and metastasis.

Up-regulation of AURKA is ubiquitous in a wide range of human malignancies, and its activation has been shown to play an important role in a wide range of cancers, and several AURKA substrates have been identified, which include mitotic regulators, tumour suppressors or oncogenes. suppressors or oncogenes. In addition, AURKA is also strongly associated with tumour immunity, as its antigenic determinants can initiate an anti-AURKA immune response by killing tumour cells with high AURKA expression. Therefore, AURKA not only plays a key role in the biological process of tumour cells, but is also an important target for cancer therapy and immunotherapy.