BAG2

BAG2 encodes the BCL2-associated athanogene 2 protein, also commonly known as DKFZp564G1911. This protein is a member of the BAG family, which modulates the anti - apoptotic activity of Bcl - 2. BAG2 binds to the ATPase domain of Hsc70/Hsp70 and regulates chaperone activity. It is involved in the PI3K - Akt signaling pathway, which is crucial for cell survival and growth.
Dysregulation of BAG2 has been linked to various diseases, such as neurodegenerative disorders and cancer. In cancer, it may contribute to tumor cell survival and resistance to chemotherapy. Currently, research is ongoing to develop drugs that target the interaction between BAG2 and its binding partners, aiming to disrupt the signaling pathways and combat related diseases.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BAG2 Recombinant Monoclonal Antibody (CSB-RA104772A0HU)

Validated Data

Western Blot
Positive WB detected in: Hela whole cell lysate(30µg), Jurkat whole cell lysate(30µg), PC-3 whole cell lysate(30µg)
All lanes: BAG2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 24 kDa
Observed band size: 24 kDa
Exposure time：1min

BAG2 Antibody (CSB-PA002530ESR1HU)

Validated Data

Western blot
All lanes: BAG family molecular chaperone regulator 2 antibody at 6μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 24, 21 kDa
Observed band size: 24 kDa

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA002530ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002530ESR1HU at dilution of 1:100

The following BAG2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BAG2 Antibodies

BAG2 Proteins

BAG2 Antibodies

BAG2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002530ESR1HU	BAG2 Antibody	Human	ELISA, WB, IHC
CSB-RA104772A0HU	BAG2 Recombinant Monoclonal Antibody	Human	ELISA, WB

BAG2 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA604500XA01DOA	BAG2 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

BAG2 Proteins

BAG2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP002530HU CSB-BP002530HU CSB-MP002530HU CSB-EP002530HU-B	Recombinant Human BAG family molecular chaperone regulator 2 (BAG2)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP002530HU	Recombinant Human BAG family molecular chaperone regulator 2 (BAG2)	E.coli

BAG2 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP604500DOA CSB-EP604500DOA CSB-BP604500DOA CSB-MP604500DOA CSB-EP604500DOA-B	Recombinant Arabidopsis thaliana BAG family molecular chaperone regulator 2 (BAG2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BAG2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP835596MO CSB-EP835596MO CSB-BP835596MO CSB-MP835596MO CSB-EP835596MO-B	Recombinant Mouse BAG family molecular chaperone regulator 2 (Bag2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

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Hippo signaling pathway

TGF-beta signaling pathway

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BAG2

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