BRD2

Bromodomain-containing protein 2 (BRD2), also known as RING3 or BRD2B, is a chromatin reader that binds acetylated lysine residues on histone tails via its two bromodomains. This interaction modulates chromatin structure, recruits transcriptional complexes, and regulates genes involved in cell cycle progression, proliferation, and differentiation. It participates in Wnt/β-catenin and NF-κB signaling pathways, enhancing target gene transcription.
BRD2 is linked to Facioscapulohumeral muscular dystrophy (FSHD) due to its proximity to the FSHD-associated D4Z4 locus and interaction with FRG1. Overexpression occurs in hematological malignancies (leukemia, lymphoma) and solid tumors (breast, prostate). BET inhibitors like JQ1, targeting BRD2’s bromodomains, are in preclinical/clinical trials for cancer, blocking its transcriptional activity to suppress oncogenic pathways.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BRD2 Recombinant Monoclonal Antibody (CSB-RA972223A0HU)

Validated Data

Overlay Peak curve showing Hela cells stained with CSB-RA972223A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

The following BRD2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BRD2 Antibodies

BRD2 Proteins

BRD2 Antibodies

BRD2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-RA972223A0HU	BRD2 Recombinant Monoclonal Antibody	Human	ELISA, FC

BRD2 Proteins

BRD2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP002800HU CSB-MP002800HU CSB-EP002800HU-B	Recombinant Human Bromodomain-containing protein 2 (BRD2), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP002800HU1	Recombinant Human Bromodomain-containing protein 2 (BRD2), partial	E.coli
CSB-EP002800HU	Recombinant Human Bromodomain-containing protein 2 (BRD2), partial	E.coli
CSB-YP002800HU	Recombinant Human Bromodomain-containing protein 2 (BRD2), partial	Yeast
CSB-YP002800HU1	Recombinant Human Bromodomain-containing protein 2 (BRD2), partial	Yeast
CSB-YP002800HUp3	Recombinant Human Bromodomain-containing protein 2 (BRD2), partial	Yeast

BRD2 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP657710BO CSB-EP657710BO CSB-BP657710BO CSB-MP657710BO CSB-EP657710BO-B	Recombinant Bovine Bromodomain-containing protein 2 (BRD2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRD2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP719429DO CSB-EP719429DO CSB-BP719429DO CSB-MP719429DO CSB-EP719429DO-B	Recombinant Dog Bromodomain-containing protein 2 (BRD2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRD2 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP741953MO CSB-EP741953MO CSB-BP741953MO CSB-MP741953MO CSB-EP741953MO-B	Recombinant Mouse Bromodomain-containing protein 2 (Brd2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BRD2 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP761061RA CSB-EP761061RA CSB-BP761061RA CSB-MP761061RA CSB-EP761061RA-B	Recombinant Rat Bromodomain-containing protein 2 (Brd2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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BRD2

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