BRD4 is a protein in humans that is encoded by BRD4 gene. Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II.
The following BRD4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
BRD4 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA577233 | BRD4 Antibody |
Human,Mouse | ELISA,WB |
CSB-PA249846 | BRD4 Antibody |
Human,Mouse | ELISA,WB |
CSB-PA002802LA01HU | BRD4 Antibody |
Human | ELISA, IF |
CSB-PA002802LD01HU | BRD4 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA152430A0HU | BRD4 Recombinant Monoclonal Antibody |
Human | ELISA, WB, IHC |
BRD4 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA564965XA01DIL | brd4 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
BRD4 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP002802HU CSB-BP002802HU CSB-MP002802HU CSB-EP002802HU-B |
Recombinant Human Bromodomain-containing protein 4 (BRD4), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRD4 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP887677MO CSB-EP887677MO CSB-BP887677MO CSB-MP887677MO CSB-EP887677MO-B |
Recombinant Mouse Bromodomain-containing protein 4 (Brd4), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRD4 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL002802HU | Human Bromodomain-containing protein 4(BRD4) ELISA kit |
serum, plasma, tissue homogenates | 4.68 pg/mL |