CCN5

CCN5 encodes WNT1 inducible signaling pathway protein 2 (WISP2), a secreted matricellular protein of the CCN family (aliases: WISP2). It regulates cell proliferation, differentiation, and migration by interacting with extracellular matrix components and cell surface receptors, inhibiting epithelial-mesenchymal transition (EMT) via Wnt/β-catenin and TGF-β pathways to preserve epithelial cell polarity.
Dysregulated CCN5 is linked to breast cancer (reduced expression correlates with metastasis), obesity, and metabolic syndrome. Preclinical studies explore WISP2 peptide mimetics to suppress tumor invasion and small molecules targeting its regulatory pathways for metabolic disorders; no approved drugs exist yet, but its EMT-modulating role makes it a promising therapeutic target.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

WISP2 Antibody (CSB-PA026120ESR1HU)

Validated Data

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026120ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA026120ESR1HU at dilution of 1:100

Human WNT1-inducible-signaling pathway protein 2(WISP2) ELISA kit (CSB-EL026120HU)

Validated Data

Code: CSB-EL026120HU

Size: 96T,5×96T,10×96T

Sensitivity: 0.039 ng/mL

Detection Range: 0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CCN5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CCN5 Antibodies

CCN5 Proteins

CCN5 ELISA Kits

CCN5 Antibodies

CCN5 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA026120ESR1HU	WISP2 Antibody	Human	ELISA, IHC
CSB-PA968927	WISP2 Antibody	Human	ELISA,WB
CSB-PA026120LA01HU	WISP2 Antibody	Human	ELISA, IHC
CSB-PA026120LB01HU	WISP2 Antibody, HRP conjugated	Human	ELISA
CSB-PA026120LC01HU	WISP2 Antibody，FITC conjugated	Human
CSB-PA026120LD01HU	WISP2 Antibody，Biotin conjugated	Human	ELISA

CCN5 Proteins

CCN5 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP026120HU CSB-BP026120HU CSB-MP026120HU CSB-EP026120HU-B	Recombinant Human CCN family member 5 (CCN5)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP026120HU(A4)	Recombinant Human CCN family member 5 (CCN5)	E.coli
CSB-EP026120HU(A4)d7	Recombinant Human CCN family member 5 (CCN5)	E.coli

CCN5 ELISA Kit

CCN5 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL026120HU	Human WNT1-inducible-signaling pathway protein 2(WISP2) ELISA kit	serum, plasma, tissue homogenates	0.039 ng/mL

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

CCN5

Popular Product: