Cyclin-H is a protein in humans that is encoded by CCNH gene. Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

CCNH Antibodies

CCNH Antibodies for Homo sapiens (Human)

CCNH Proteins

CCNH Proteins for Homo sapiens (Human)

CCNH Proteins for Xenopus laevis (African clawed frog)

CCNH Proteins for Bos taurus (Bovine)

CCNH Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CCNH Proteins for Mus musculus (Mouse)

CCNH Proteins for Rattus norvegicus (Rat)


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