CDK12

CDK12, full name cyclin dependent kinase 12. It maintains normal cell cycle progression, genome stability and DNA damage repair, supporting orderly proliferation of normal human cells.
Dysfunctional CDK12 causes genome instability, metastasis and drug resistance in breast, ovarian and prostate cancers. Selective CDK12 inhibitors are in preclinical and early clinical anti-tumor trials.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CDK12 Antibody (CSB-PA998940)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA998940(CDK12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA998940(CDK12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The following CDK12 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CDK12 Antibodies

CDK12 Proteins

CDK12 Antibodies

CDK12 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA998940	CDK12 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA882147LA01HU	CDK12 Antibody	Human	ELISA, WB

CDK12 Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA894718XA01DLU	Cdk12 Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

CDK12 Proteins

CDK12 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP005981XBF CSB-EP005981XBF CSB-BP005981XBF CSB-MP005981XBF CSB-EP005981XBF-B	Recombinant Xenopus tropicalis Cyclin-dependent kinase 12 (cdk12), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CDK12 Proteins for Ailuropoda melanoleuca (Giant panda)

Code	Product Name	Source
CSB-YP005981AYX CSB-EP005981AYX CSB-BP005981AYX CSB-MP005981AYX CSB-EP005981AYX-B	Recombinant Ailuropoda melanoleuca Cyclin-dependent kinase 12 (CDK12), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CDK12 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP005981BO CSB-EP005981BO CSB-BP005981BO CSB-MP005981BO CSB-EP005981BO-B	Recombinant Bovine Cyclin-dependent kinase 12 (CDK12), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CDK12 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP622934MO CSB-EP622934MO CSB-BP622934MO CSB-MP622934MO CSB-EP622934MO-B	Recombinant Mouse Cyclin-dependent kinase 12 (Cdk12), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CDK12 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP659533RA CSB-EP659533RA CSB-BP659533RA CSB-MP659533RA CSB-EP659533RA-B	Recombinant Rat Cyclin-dependent kinase 12 (Cdk12), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CDK12 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP882147HU CSB-MP882147HU CSB-EP882147HU-B	Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882147HU	Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial	E.coli
CSB-EP882147HUc7	Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial	E.coli
CSB-EP882147HUb0	Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial	E.coli
CSB-BP882147HU	Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial	Homo sapiens (Human)
CSB-BP882147HUa0	Recombinant Human Cyclin-dependent kinase 12 (CDK12), partial	Homo sapiens (Human)

CDK12 Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP894718DLU CSB-BP894718DLU CSB-MP894718DLU CSB-EP894718DLU-B	Recombinant Drosophila melanogaster Cyclin-dependent kinase 12 (Cdk12), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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CDK12

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