CH25H

The gene CH25H encodes the protein Cholesterol-25-hydroxylase, also known as Cholesterol-25-monooxygenase. This enzyme is primarily localized in the endoplasmic reticulum and Golgi apparatus, where it catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC). CH25H plays a crucial role in regulating cholesterol metabolism by converting cholesterol into 25HC, which is a key regulator of lipid metabolism and inflammation. The protein is a member of the interferon-stimulated gene (ISG) family, indicating its involvement in immune responses, particularly in antiviral defense. CH25H's activity is upregulated in response to viral infections and Toll-like receptor (TLR) agonists, highlighting its role in innate immunity. Dysregulation of CH25H has been associated with various diseases, including atherosclerosis and certain viral infections, suggesting its potential as a therapeutic target in drug development.