CKAP4

CKAP4, also known as cytoskeleton-associated protein 4, has alternative names including p63, CLIMP63, and ERGIC-63. CKAP4 is a type II transmembrane protein primarily localized on the cell membrane and rough endoplasmic reticulum. It serves as a receptor for various ligands and plays a crucial role in stabilizing protein structures. CKAP4 is involved in numerous biological activities, including cell proliferation, cell migration, keratinocyte differentiation, glycan synthesis, fibrosis, thymus development, heart formation, neuronal apoptosis, and cancer progression. CKAP4 and its isoforms bind to DKK1 or DKK3 (Dickkopf protein) or anti-proliferative factor (APF), regulating several downstream signaling cascades such as the PI3K/AKT and MAPK1/3 pathways. The CKAP4 complex plays a key role in signal pathway regulation and is a potential target for cancer therapy.