CTSS

CTSS, or histone protease S, alias CathepsinS, Cats, CatS. CTSS is encoded by the human CTSS gene, which is located on chromosome 1 in the region 1q21.3.
CTSS is a lysosomal cysteine protease belonging to the family of peptidases C1, which is involved in the degradation of antigenic proteins into peptides for presentation to MHC class II molecules. CTSS also possesses elastase activity, which extracellularly remodels components of the extracellular matrix.
CTSS has been implicated in the pathology of a variety of inflammatory and autoimmune diseases and plays an important role in certain lung diseases due to its elastase activity. Aberrant expression and regulation of CTSS has been implicated in the pathogenesis of a variety of diseases, including lung diseases, such as pulmonary fibrosis, in which overexpression of CTSS causes multiple pathological processes, including pulmonary fibrosis, increased CTSS secretion and accelerated extracellular matrix remodeling.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CTSS Recombinant Monoclonal Antibody (CSB-RA788455A0HU)

Validated Data

IHC image of CSB-RA788455A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA788455A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Cathepsin S (CTSS) ELISA Kit (CSB-E13722h)

Validated Data

Code: CSB-E13722h

Size: 96T,5×96T,10×96T

Sensitivity: 15.6 pg/mL

Detection Range: 62.5 pg/mL- 4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CTSS reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CTSS Antibodies

CTSS Proteins

CTSS ELISA Kits

CTSS Antibodies

CTSS Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA10729A0Rb	CTSS Antibody	Human	ELISA, WB, IHC
CSB-RA788455A0HU	CTSS Recombinant Monoclonal Antibody	Human	ELISA, IHC

CTSS Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA006204LA01MO	Ctss Antibody	Mouse	ELISA
CSB-PA006204LB01MO	Ctss Antibody, HRP conjugated	Mouse	ELISA

CTSS Proteins

CTSS Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP006204RA CSB-EP006204RA CSB-BP006204RA CSB-MP006204RA CSB-EP006204RA-B	Recombinant Rat Cathepsin S (Ctss)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSS Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP006204HU CSB-BP006204HU CSB-MP006204HU CSB-EP006204HU-B	Recombinant Human Cathepsin S (CTSS)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006204HU	Recombinant Human Cathepsin S (CTSS)	E.coli

CTSS Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP006204BO CSB-EP006204BO CSB-BP006204BO CSB-MP006204BO CSB-EP006204BO-B	Recombinant Bovine Cathepsin S (CTSS)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSS Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP006204MO CSB-BP006204MO CSB-MP006204MO CSB-EP006204MO-B	Recombinant Mouse Cathepsin S (Ctss)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006204MO	Recombinant Mouse Cathepsin S (Ctss)	E.coli

CTSS Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP006204DO CSB-EP006204DO CSB-BP006204DO CSB-MP006204DO CSB-EP006204DO-B	Recombinant Dog Cathepsin S (CTSS)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSS Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

Code	Product Name	Source
CSB-YP006204SWC CSB-BP006204SWC CSB-MP006204SWC CSB-EP006204SWC-B	Recombinant Saimiri boliviensis boliviensis Cathepsin S (CTSS)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli