CXCR2 (C-X-C motif chemokine receptor 2), also known as interleukin-8 receptor β (IL8RB) or CD182, is a G protein-coupled receptor (GPCR) that binds ELR+ CXC chemokines including IL-8 (CXCL8) and growth-regulated oncogene-α (GROα/CXCL1). It mediates neutrophil chemotaxis, angiogenesis, and inflammatory responses through activation of Gαi-mediated pathways, triggering downstream MAPK, PI3K/AKT, and β-arrestin signaling cascades. Aberrant CXCR2 activation is implicated in chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, atherosclerosis, and cancer metastasis by promoting leukocyte infiltration and tumor microenvironment remodeling. Several small-molecule antagonists (e.g., AZD5069, navarixin) and monoclonal antibodies targeting CXCR2 or its ligands have reached clinical trials for inflammatory diseases and oncology applications. However, challenges remain in balancing therapeutic efficacy with potential immunosuppressive effects, particularly neutropenia. Recent research explores biased signaling modulation to dissociate anti-inflammatory benefits from adverse effects.
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial (CSB-EP011673HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCR2 Antibody (CSB-PA011673HA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA011673HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011673HA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA011673HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following CXCR2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CXCR2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011673GA01HU | CXCR2 Antibody | Human | ELISA,WB,IF |
CSB-PA974167 | Phospho-CXCR2 (Ser347) Antibody | Human,Mouse | ELISA,WB |
CSB-PA005633 | CXCR2 Antibody | Human | WB, ELISA |
CSB-PA009566 | Phospho-CXCR2 (S347) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA009567 | CXCR2 Antibody | Human,Mouse | IF, ELISA |
CSB-PA730026 | CXCR2 Antibody | Human | ELISA,WB |
CSB-PA282080 | CXCR2 Antibody | Human | ELISA,WB |
CSB-PA011673HA01HU | CXCR2 Antibody | Human | ELISA, IHC, IF |
CSB-PA011673HB01HU | CXCR2 Antibody, HRP conjugated | Human | ELISA |
CXCR2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP011673HU | Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial | E.coli |
CSB-CF011673HU(A4) | Recombinant Human C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP011673HU CSB-BP011673HU CSB-MP011673HU CSB-EP011673HU-B |
Recombinant Human C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-CF630684MOW | Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP630684MOW1 CSB-EP630684MOW1 CSB-BP630684MOW1 CSB-MP630684MOW1 CSB-EP630684MOW1-B |
Recombinant Macaca mulatta C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
Code | Product Name | Source |
---|---|---|
CSB-CF636722GGZ | Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP636722GGZ1 CSB-EP636722GGZ1 CSB-BP636722GGZ1 CSB-MP636722GGZ1 CSB-EP636722GGZ1-B |
Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF011673DO | Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP011673DO1 CSB-EP011673DO1 CSB-BP011673DO1 CSB-MP011673DO1 CSB-EP011673DO1-B |
Recombinant Dog C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-CF631729EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP631729EQV1 CSB-EP631729EQV1 CSB-BP631729EQV1 CSB-MP631729EQV1 CSB-EP631729EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-CF011673RB | Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP011673RB1 CSB-EP011673RB1 CSB-BP011673RB1 CSB-MP011673RB1 CSB-EP011673RB1-B |
Recombinant Rabbit C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF011673RA | Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2) | in vitro E.coli expression system |
CSB-YP011673RA1 CSB-EP011673RA1 CSB-BP011673RA1 CSB-MP011673RA1 CSB-EP011673RA1-B |
Recombinant Rat C-X-C chemokine receptor type 2 (Cxcr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CXCR2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF011673MO | Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2) | in vitro E.coli expression system |
CSB-YP011673MO1 CSB-EP011673MO1 CSB-BP011673MO1 CSB-MP011673MO1 CSB-EP011673MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP011673MO | Recombinant Mouse C-X-C chemokine receptor type 2 (Cxcr2)-VLPs | Mammalian cell |
CXCR2 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF632950BO | Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2) | in vitro E.coli expression system |
CSB-YP632950BO1 CSB-EP632950BO1 CSB-BP632950BO1 CSB-MP632950BO1 CSB-EP632950BO1-B |
Recombinant Bovine C-X-C chemokine receptor type 2 (CXCR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |