Discoid domain receptors (DDRs) are a class of receptor-type tyrosine kinases (RTKs), which can be divided into DDR1 and DDR2, and play an important role in cell adhesion, proliferation and extracellular matrix remodeling. Like other tyrosine protein kinase receptors, DDR1 is autophosphorylated at the ligand binding site. But the difference is that phosphorylation of DDR1 is unusually slow and long-lasting. At present, there are many reports that DDR1 is overexpressed in human tumors such as primary breast cancer, ovarian cancer, and esophageal cancer, and can even reach three times the normal value in childhood brain tumors, and DDR1 mainly exists in highly infiltrating tumor cells. middle. The study also found that overexpression and gain-of-function mutation of DDR1 can increase tumorigenicity in tumor model animals, and knockout of DDR1 gene can inhibit tumorigenesis and metastasis. These pieces of evidence suggest that DDR1 is likely to be a target for anticancer drug development.
Validated Data
The purity was greater than 95% as determined by SDS-PAGE. (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Immobilized Human DDR1 at 2 μg/ml can bind Anti-DDR1 recombinant antibody (CSB-RA006595MA1HU), the EC50 is 2.824-3.810 ng/mL
The following DDR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DDR1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA198834 | DDR1 (Ab-796) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA978355 | DDR1 Antibody | Human | ELISA,WB |
CSB-PA000715 | Phospho-DDR1 (Y513) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA002098 | DDR1 Antibody | Human | WB, ELISA |
CSB-PA060123 | DDR1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-RA006595MA1HU | DDR1 Recombinant Monoclonal Antibody | Human | ELISA |
DDR1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP730899RA CSB-EP730899RA CSB-BP730899RA CSB-MP730899RA CSB-EP730899RA-B |
Recombinant Rat Epithelial discoidin domain-containing receptor 1 (Ddr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDR1 Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP771987EQV CSB-EP771987EQV CSB-BP771987EQV CSB-MP771987EQV CSB-EP771987EQV-B |
Recombinant Pan troglodytes Epithelial discoidin domain-containing receptor 1 (DDR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DDR1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-MP006595HU | Recombinant Human Epithelial discoidin domain-containing receptor 1 (DDR1), partial (Active) | Mammalian cell |