Egl nine homolog 2 is a protein in humans that is encoded by EGLN2 gene. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle.
The following EGLN2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EGLN2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007482GA01HU | EGLN2 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA007482EA01HU | EGLN2 Antibody |
Human | ELISA, IHC, IF |
EGLN2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP738149RA CSB-EP738149RA CSB-BP738149RA CSB-MP738149RA CSB-EP738149RA-B |
Recombinant Rat Egl nine homolog 2 (Egln2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EGLN2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP849679MO CSB-EP849679MO CSB-BP849679MO CSB-MP849679MO CSB-EP849679MO-B |
Recombinant Mouse Egl nine homolog 2 (Egln2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EGLN2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP007482HU | Recombinant Human Egl nine homolog 2 (EGLN2), partial |
E.coli |
CSB-YP007482HU CSB-BP007482HU CSB-MP007482HU CSB-EP007482HU-B |
Recombinant Human Egl nine homolog 2 (EGLN2), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |