FLT3LG

FLT3LG, or FMS-associated tyrosine kinase 3 ligand, alias FLT3 ligand.FLT3LG is a protein that in humans is encoded by the FLT3LG gene. Its mechanism of action is to promote early hematopoietic cell proliferation by activating its receptor FLT3, which has a good synergy with various other colony-stimulating factors and interleukins.FLT3LG initiates growth and differentiation by binding to the FLT3 receptor and triggering homodimerization and autophosphorylation of the receptor, which activates the downstream signaling pathways such as PI3K/AKT and Ras/MAPK, initiating a growth and differentiation The biological significance of FLT3LG lies mainly in its regulation of the proliferation and differentiation of hematopoietic stem and progenitor cells (HSPC).

Mutations in the FLT3LG gene can lead to severe immunodeficiencies manifested by myelodysplasia, a significant reduction in HSPC, and a lack of monocytes and dendritic cells. In addition, FLT3LG is essential for the differentiation of monocytes and dendritic cells, which play a key role in the body's immune defense.The discovery of FLT3LG not only extends our understanding of the molecular mechanisms controlling the development of the hematopoietic spectrum, but also underscores the important role of FLT3LG in the immune defense, particularly in the immune response against a variety of pathogens including HPV in the immune response against various pathogens, including HPV.