FOXM1

Forkhead box protein M1 (FOXM1), also known as Trident or HFH-11, is a key transcription factor. It regulates cell cycle progression, DNA damage repair, and apoptosis through binding to specific DNA sequences. FOXM1 is involved in multiple signaling pathways such as the Wnt/β-catenin pathway.
Aberrant expression of FOXM1 is linked to various diseases, especially cancers including breast, lung, and colon cancer. Due to its crucial role in tumor growth and metastasis, FOXM1 has become an attractive target for drug development. Some small - molecule inhibitors are under pre - clinical and clinical investigations to explore their therapeutic potential.