FZD10

Frizzled 10 (FZD10), a seven-transmembrane G protein-coupled receptor (GPCR) in the Frizzled family, has aliases including Fz-10 and CD350. It acts as a key receptor for Wnt ligands, mediating canonical (β-catenin-dependent) and non-canonical Wnt pathways to regulate cell proliferation, differentiation, and embryonic tissue patterning.
Dysregulated FZD10 is associated with colorectal, gastric, and pancreatic cancers, where overexpression correlates with tumor progression. Preclinical research targets FZD10 via monoclonal antibodies (blocking ligand binding) or small molecules to inhibit aberrant Wnt signaling, suppressing tumor growth and stemness—positioning it as a promising therapeutic target for malignancies.