GPR45

GPR45 is a member of the G protein-coupled receptor (GPCR) superfamily, officially named G protein-coupled receptor 45. It is also known by aliases such as GPR45_HUMAN. As a class A GPCR, GPR45 likely functions by coupling to G proteins upon ligand binding, thereby initiating intracellular signaling cascades, though its endogenous ligands remain poorly characterized.
GPR45 has been implicated in regulating metabolic processes and may be associated with pathways involved in glucose homeostasis and lipid metabolism. Emerging studies suggest potential links to metabolic disorders, including type 2 diabetes and obesity, though its precise role in disease pathogenesis requires further investigation. Currently, there are no specific therapeutic agents targeting GPR45 in clinical development, highlighting the need for more research into its ligand specificity and physiological functions.