GRIN2B

The GRIN2B gene encodes the N-methyl D-aspartate receptor subtype 2B (NMDAR2B), a protein involved in synaptic transmission and plasticity. Known as GluN2B, it is a crucial component of the NMDA receptor complex, which plays a pivotal role in excitatory neurotransmission. GRIN2B dysfunction is associated with various neurological disorders, including childhood-onset epilepsy, developmental delays, and movement disorders, often linked to autism spectrum disorder. Research into GRIN2B's signaling pathways has identified its involvement in calcium influx and synaptic plasticity, offering potential targets for drug development. Current drug research focuses on modulating NMDA receptor activity to treat GRIN2B-related conditions.