HLA-G (Human Leukocyte Antigen-G) is a member of the Human Leukocyte Antigen (HLA) family and plays a crucial role in immune regulation. Unlike the MHC-Ia molecules (HLA-A, B, C, etc.), HLA-G is an MHC-Ib molecule whose expression is tightly regulated. It has a specific structure composed of an α chain and β2 microglobulin chain, forming subtypes of HLA-G molecules. One of the main functions of HLA-G is immune regulation. It can inhibit immune cells' recognition of specific antigens, modulate T cell activity, and suppress autoimmune reactions, aiding in maintaining immune tolerance of the fetus in the maternal uterus. HLA-G also participates in immune evasion, helping the fetus and certain tumor cells evade attacks from the immune system, thereby promoting their survival and growth. While the exact signaling pathways involving HLA-G encompass various cytokines and signaling molecules, the mechanisms through which it regulates immune responses and controls cellular immune evasion are not entirely elucidated. The unique functions and mechanisms of HLA-G make it a hot topic in research, potentially serving as an important target for future therapies and diagnostics.
Recombinant Human HLA class I histocompatibility antigen, alpha chain G (HLA-G)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP010509HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens(Human) HLA-G.
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of CSB-MP010509HU could indicate that this peptide derived from Mammalian Cell-expressed Homo sapiens(Human) HLA-G.
The following HLA-G reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
HLA-G Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA02109D0Rb | HLA-G Antibody, Biotin conjugated | Human | ELISA |
CSB-PA02109B0Rb | HLA-G Antibody, HRP conjugated | Human | ELISA |
CSB-PA02109A0Rb | HLA-G Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA010509ESR2HU | HLA-G Antibody | Human | ELISA, IHC |
CSB-PA010509LA01HU | HLA-G Antibody | Human | ELISA, WB |
CSB-PA010509LB01HU | HLA-G Antibody, HRP conjugated | Human | ELISA |
CSB-PA010509LC01HU | HLA-G Antibody, FITC conjugated | Human | |
CSB-PA010509LD01HU | HLA-G Antibody, Biotin conjugated | Human | ELISA |
CSB-RA117800A0HU | HLA-G Recombinant Monoclonal Antibody | Human | ELISA, FC |
HLA-G Proteins for Homo sapiens (Human)
HLA-G ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09401h | Human leukocyte antigen G,HLA-G ELISA Kit | serum, plasma, tissue homogenates | 0.31 ng/mL |