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E3 ubiquitin-protein ligase HUWE1 is a protein in humans that is encoded by HUWE1 gene. E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN.
The following HUWE1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
HUWE1 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010911RA CSB-EP010911RA CSB-BP010911RA CSB-MP010911RA CSB-EP010911RA-B |
Recombinant Rat E3 ubiquitin-protein ligase HUWE1 (Huwe1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HUWE1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP763099MO CSB-EP763099MO CSB-BP763099MO CSB-MP763099MO CSB-EP763099MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase HUWE1 (Huwe1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HUWE1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP773604HU CSB-BP773604HU CSB-MP773604HU CSB-EP773604HU-B |
Recombinant Human E3 ubiquitin-protein ligase HUWE1 (HUWE1), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
