IGF2BP3, the insulin-like growth factor 2 mRNA-binding protein 3, is an RNA-binding protein that comprises RNA-binding domains, RRM domains, and protein-interaction domains. It regulates cell proliferation, differentiation, and survival by binding to mRNAs and promoting their stability and translation. IGF2BP3 plays a pivotal role in various biological processes, particularly in development, tumorigenesis, and stem cell formation. As an N6-adenosine methylation reader protein, it can also recognize m6A GC sequences, influencing the stability and translation of downstream target mRNAs. Regarding its signaling pathway, IGF2BP3 may interact with specific molecules or proteins to form complex signaling networks. For instance, in colorectal cancer, it collaborates with METTL14 to promote the stability and translation of EGFR mRNA in an m6A-dependent manner, thereby activating the EGFR pathway. Therefore, further elucidating the signaling pathway and regulatory mechanism of IGF2BP3 is crucial for understanding its biological functions and developing novel therapeutic strategies.
● Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HEK293 whole cell lysate, Mouse brain tissue
All lanes: IGF2BP3 antibody at 2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 64, 22 kDa
Observed band size: 64, 50 kDa
Immunofluorescent analysis of MCF-7 cells using CSB-PA011092LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of MCF-7 cells using CSB-PA011092LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011092LA01HU at dilution of 1:100
The following IGF2BP3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IGF2BP3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011092GA01HU | IGF2BP3 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA745585 | IGF2BP3 Antibody |
Human,Mouse | ELISA,WB |
CSB-PA011092LA01HU | IGF2BP3 Antibody |
Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA011092LB01HU | IGF2BP3 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA011092LC01HU | IGF2BP3 Antibody, FITC conjugated |
Human | |
CSB-PA011092LD01HU | IGF2BP3 Antibody, Biotin conjugated |
Human | ELISA |
IGF2BP3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP011092HU CSB-BP011092HU CSB-MP011092HU CSB-EP011092HU-B |
Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011092HU | Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) |
E.coli |
IGF2BP3 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011092HU | Human Insulin-like growth factor 2 mRNA-binding protein 3(IGF2BP3) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 9.37 pg/mL |