Interleukin-17C is a protein in humans that is encoded by IL17C gene. Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
The following IL17C reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL17C Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA809269 | IL17C Antibody |
Human | ELISA,WB,IHC |
CSB-PA959846 | IL17C Antibody |
Human | ELISA,WB,IHC |
CSB-PA301181 | IL17C Antibody |
Human | IHC,ELISA |
IL17C Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP889169HU CSB-EP889169HU CSB-BP889169HU CSB-MP889169HU CSB-EP889169HU-B |
Recombinant Human Interleukin-17C (IL17C) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL17C ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E15917h | Human Interleukin17C (IL17C) ELISA Kit |
serum, plasma, tissue homogenates | 0.039 ng/ml |