IRS4

Insulin receptor substrate 4 is a protein in humans that is encoded by IRS4 gene. Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation.

The following IRS4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IRS4 Antibodies

IRS4 Proteins

IRS4 Antibodies

IRS4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA294860	IRS4 Antibody	Human	ELISA,IHC

IRS4 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

Code	Product Name	Species Reactivity	Application
CSB-PA741605XA01DOT	IRS4 Antibody	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)	ELISA, WB (ensure identification of antigen)

IRS4 Antibodies for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA409775XA01STA	IRS4 Antibody	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

IRS4 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA327492XA01SVG	IRS4 Antibody	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

IRS4 Proteins

IRS4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP011832HU CSB-EP011832HU CSB-BP011832HU CSB-MP011832HU CSB-EP011832HU-B	Recombinant Human Insulin receptor substrate 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Source
CSB-YP327492SVG CSB-EP327492SVG CSB-BP327492SVG CSB-MP327492SVG CSB-EP327492SVG-B	Recombinant Saccharomyces cerevisiae Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

Code	Product Name	Source
CSB-YP373670AVC CSB-EP373670AVC CSB-BP373670AVC CSB-MP373670AVC CSB-EP373670AVC-B	Recombinant Aspergillus clavatus Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)

Code	Product Name	Source
CSB-YP374038NEZ CSB-EP374038NEZ CSB-BP374038NEZ CSB-MP374038NEZ CSB-EP374038NEZ-B	Recombinant Neosartorya fischeri Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)

Code	Product Name	Source
CSB-YP382754AVE CSB-EP382754AVE CSB-BP382754AVE CSB-MP382754AVE CSB-EP382754AVE-B	Recombinant Aspergillus niger Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)

Code	Product Name	Source
CSB-YP386485SXM CSB-EP386485SXM CSB-BP386485SXM CSB-MP386485SXM CSB-EP386485SXM-B	Recombinant Scheffersomyces stipitis Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)

Code	Product Name	Source
CSB-YP391622MPM CSB-EP391622MPM CSB-BP391622MPM CSB-MP391622MPM CSB-EP391622MPM-B	Recombinant Magnaporthe oryzae Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)

Code	Product Name	Source
CSB-YP398905MTM CSB-EP398905MTM CSB-BP398905MTM CSB-MP398905MTM CSB-EP398905MTM-B	Recombinant Meyerozyma guilliermondii Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)

Code	Product Name	Source
CSB-YP399242LLV CSB-EP399242LLV CSB-BP399242LLV CSB-MP399242LLV CSB-EP399242LLV-B	Recombinant Lodderomyces elongisporus Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

Code	Product Name	Source
CSB-YP409775STA CSB-EP409775STA CSB-BP409775STA CSB-MP409775STA CSB-EP409775STA-B	Recombinant Saccharomyces cerevisiae Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)

Code	Product Name	Source
CSB-YP410708BVD CSB-EP410708BVD CSB-BP410708BVD CSB-MP410708BVD CSB-EP410708BVD-B	Recombinant Botryotinia fuckeliana Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)

Code	Product Name	Source
CSB-YP411402STG CSB-EP411402STG CSB-BP411402STG CSB-MP411402STG CSB-EP411402STG-B	Recombinant Sclerotinia sclerotiorum Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP011832MO CSB-EP011832MO CSB-BP011832MO CSB-MP011832MO CSB-EP011832MO-B	Recombinant Mouse Insulin receptor substrate 4 (Irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)

Code	Product Name	Source
CSB-YP627745DUV CSB-EP627745DUV CSB-BP627745DUV CSB-MP627745DUV CSB-EP627745DUV-B	Recombinant Coccidioides immitis Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)

Code	Product Name	Source
CSB-YP643153CHI CSB-EP643153CHI CSB-BP643153CHI CSB-MP643153CHI CSB-EP643153CHI-B	Recombinant Chaetomium globosum Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Code	Product Name	Source
CSB-YP684225NGS CSB-EP684225NGS CSB-BP684225NGS CSB-MP684225NGS CSB-EP684225NGS-B	Recombinant Neosartorya fumigata Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Code	Product Name	Source
CSB-YP701593CZD CSB-EP701593CZD CSB-BP701593CZD CSB-MP701593CZD CSB-EP701593CZD-B	Recombinant Candida albicans Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Code	Product Name	Source
CSB-YP710656EKF CSB-EP710656EKF CSB-BP710656EKF CSB-MP710656EKF CSB-EP710656EKF-B	Recombinant Emericella nidulans Increased rDNA silencing protein 4 (irs4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

Code	Product Name	Source
CSB-YP724757KBK CSB-EP724757KBK CSB-BP724757KBK CSB-MP724757KBK CSB-EP724757KBK-B	Recombinant Kluyveromyces lactis Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

Code	Product Name	Source
CSB-YP728200DIS CSB-EP728200DIS CSB-BP728200DIS CSB-MP728200DIS CSB-EP728200DIS-B	Recombinant Debaryomyces hansenii Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Code	Product Name	Source
CSB-YP728252YAP CSB-EP728252YAP CSB-BP728252YAP CSB-MP728252YAP CSB-EP728252YAP-B	Recombinant Yarrowia lipolytica Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

Code	Product Name	Source
CSB-YP738894CZI CSB-EP738894CZI CSB-BP738894CZI CSB-MP738894CZI CSB-EP738894CZI-B	Recombinant Candida glabrata Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRS4 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

Code	Product Name	Source
CSB-YP741605DOT CSB-EP741605DOT CSB-BP741605DOT CSB-MP741605DOT CSB-EP741605DOT-B	Recombinant Ashbya gossypii Increased rDNA silencing protein 4 (IRS4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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