KLHDC3

KLHDC3 encodes Kelch domain-containing protein 3, a substrate adaptor for Cullin-RING E3 ubiquitin ligases. It mediates ubiquitination and proteasomal degradation of target proteins, regulating cellular proliferation and differentiation. A common alias is KIAA1468.
Dysregulation of KLHDC3 is linked to lung and breast cancers; its overexpression in tumors correlates with aggressive growth and poor prognosis, likely via modulating oncogenic signaling pathways. While no KLHDC3-targeted drugs are clinically available, preclinical studies explore inhibiting its ligase activity as a potential therapeutic strategy.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KLHDC3 Antibody (CSB-PA858414ZA01HU)

Validated Data

Western Blot
Positive WB detected in: recombinant protein
All lanes: KLHDC3 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

The following KLHDC3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KLHDC3 Antibodies

KLHDC3 Proteins

KLHDC3 Antibodies

KLHDC3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA858414ZA01HU	KLHDC3 Antibody	Homo sapiens	ELISA, WB

KLHDC3 Proteins

KLHDC3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP858414HU CSB-MP858414HU CSB-EP858414HU-B	Recombinant Human Kelch domain-containing protein 3 (KLHDC3)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP858414HU	Recombinant Human Kelch domain-containing protein 3 (KLHDC3)	E.coli
CSB-BP858414HU	Recombinant Human Kelch domain-containing protein 3 (KLHDC3)	Baculovirus
CSB-EP858414HUc7	Recombinant Human Kelch domain-containing protein 3 (KLHDC3)	E.coli
CSB-EP858414HUa0	Recombinant Human Kelch domain-containing protein 3 (KLHDC3)	E.coli

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Popular Pathways

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KLHDC3

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