Mannan-binding lectin serine protease 1 is a protein in humans that is encoded by MASP1 gene. Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
The following MASP1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MASP1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA000076 | Cleaved-MASP1 (R448) Antibody |
Human | WB, ELISA |
CSB-PA013508LA01HU | MASP1 Antibody |
Human | ELISA, WB |
CSB-PA013508LD01HU | MASP1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA013508LC01HU | MASP1 Antibody, FITC conjugated |
Human | |
CSB-PA013508LB01HU | MASP1 Antibody, HRP conjugated |
Human | ELISA |
MASP1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP013508MO CSB-EP013508MO CSB-BP013508MO CSB-MP013508MO CSB-EP013508MO-B |
Recombinant Mouse Mannan-binding lectin serine protease 1 (Masp1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MASP1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP013508HU | Recombinant Human Mannan-binding lectin serine protease 1 (MASP1) |
Yeast |
CSB-EP013508HU | Recombinant Human Mannan-binding lectin serine protease 1 (MASP1) |
E.coli |
CSB-BP013508HU CSB-MP013508HU CSB-EP013508HU-B |
Recombinant Human Mannan-binding lectin serine protease 1 (MASP1) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MASP1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E17965h | Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1)ELISA kit |
serum, plasma, tissue homogenates | 0.78 ng/mL |