MDM2

E3 ubiquitin-protein ligase Mdm2 is a protein in humans that is encoded by MDM2 gene. E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation

MDM2 Antibodies

MDM2 Antibodies for Homo sapiens (Human)

MDM2 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

MDM2 Proteins

MDM2 Proteins for Mus musculus (Mouse)

MDM2 Proteins for Equus caballus (Horse)

MDM2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

MDM2 Proteins for Xenopus laevis (African clawed frog)

MDM2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MDM2 Proteins for Mesocricetus auratus (Golden hamster)

MDM2 Proteins for Felis catus (Cat) (Felis silvestris catus)

MDM2 cDNA for Felis catus (Cat) (Felis silvestris catus)

Code Product Name Vector Accession NO.
CSB-CL770328CA MDM2 pUC NM_001009346.1

MDM2 ELISA Kit

MDM2 ELISA Kit for Homo sapiens (Human)

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