MICA

MICA stands for MHC class I polypeptide-related sequence A. It's also known as MIC-A. This protein plays a critical role in the immune system. It functions by binding to the NKG2D receptor on natural killer cells and certain T cells, activating them to target and kill stressed or infected cells. It is involved in the NKG2D-mediated signaling pathway.
Abnormal expression of MICA is associated with various diseases, such as cancer and autoimmune disorders. In drug development, targeting the MICA - NKG2D interaction is being explored as a potential therapeutic strategy. Some pre - clinical studies are underway to evaluate agents that can modulate this interaction for better disease treatment.

Validated Data

IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.

IHC image of CSB-RA574653A0HU diluted at 1:80 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.49% DAB.

MICA Antibody (CSB-PA013806ESR2HU)

Validated Data

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013806ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA013806ESR2HU at dilution of 1:100

Human major histocompatibility complex class I chain-related gene A (MICA) ELISA Kit (CSB-E13782h)

Validated Data

Code: CSB-E13782h

Size: 96T,5×96T,10×96T

Sensitivity: 0.39 ng/mL

Detection Range: 1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following MICA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MICA Antibodies

MICA Proteins

MICA ELISA Kits

MICA Antibodies

MICA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA013806GA01HU	MICA Antibody	Human	ELISA,WB
CSB-PA013806ESR2HU	MICA Antibody	Human	ELISA, IHC
CSB-PA013806ESR1HU	MICA Antibody	Human, Mouse	ELISA, WB, IHC
CSB-RA574653A0HU	MICA Recombinant Monoclonal Antibody	Human	ELISA, IHC

MICA Proteins

MICA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP013806HU CSB-EP013806HU-B	Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-AP000251HU	Recombinant Human MHC class I polypeptide-related sequence A protein (MICA)	E.coli
CSB-AP000261HU	Recombinant Human MHC class I polypeptide-related sequence A protein (MICA)	E.coli
CSB-AP005551HU	Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial (Active)	Mammalian cell
CSB-EP013806HU	Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial	E.coli
CSB-YP013806HU	Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial	Yeast
CSB-MP013806HU	Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial	Mammalian cell

MICA ELISA Kit

MICA ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E13782h	Human major histocompatibility complex class I chain-related gene A (MICA) ELISA Kit	serum, plasma, tissue homogenates	0.39 ng/mL

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MICA

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