Code | CSB-RA574653A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
In vitro expression systems are used to generate the MICA recombinant monoclonal antibody, involving the cloning of MICA antibody DNA sequences from immunoreactive rabbits. The immunogen used is a synthesized peptide derived from the human MICA protein. Subsequently, the genes encoding the MICA antibodies are inserted into plasmid vectors, and these recombinant plasmid vectors are then transfected into host cells to enable antibody expression. Post-expression, the MICA recombinant monoclonal antibody undergoes affinity-chromatography purification and is extensively tested for functionality in ELISA and IHC applications, confirming its reactivity with the human MICA protein.
MICA is a cell surface protein that serves as a critical ligand for the NKG2D receptor on immune cells, particularly NK cells and cytotoxic T cells. Its main role is to facilitate the recognition and elimination of cells under stress, infection, or transformation, contributing to immune surveillance, anti-cancer immunity, and the immune response against various pathogens.
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