E3 ubiquitin-protein ligase MYLIP is a protein in humans that is encoded by MYLIP gene. E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
The following MYLIP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MYLIP Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015319GA01HU | MYLIP Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA003346 | MYLIP Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA855506ESR1HU | MYLIP Antibody |
Human | ELISA, IHC |
CSB-PA855506ESR2HU | MYLIP Antibody |
Human, Mouse | ELISA, WB, IHC |
MYLIP Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA807377XA01MO | Mylip Antibody |
Mus musculus (Mouse) | ELISA, WB (ensure identification of antigen) |
MYLIP Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP015319RA CSB-EP015319RA CSB-BP015319RA CSB-MP015319RA CSB-EP015319RA-B |
Recombinant Rat E3 ubiquitin-protein ligase MYLIP (Mylip) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYLIP Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP807377MO CSB-EP807377MO CSB-BP807377MO CSB-MP807377MO CSB-EP807377MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase MYLIP (Mylip) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYLIP Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP855506HU | Recombinant Human E3 ubiquitin-protein ligase MYLIP (MYLIP) |
E.coli |
CSB-YP855506HU | Recombinant Human E3 ubiquitin-protein ligase MYLIP (MYLIP) |
Yeast |
CSB-BP855506HU CSB-MP855506HU CSB-EP855506HU-B |
Recombinant Human E3 ubiquitin-protein ligase MYLIP (MYLIP) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYLIP ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL015319HU | Human E3 ubiquitin-protein ligase MYLIP(MYLIP) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 3.9 pg/mL |