NCOA4

NCOA4, also referred to as SRC-3 or p160, is a crucial co-activator of nuclear receptors, encoded by the NCOA4 gene. It collaborates with various nuclear receptors and transcription factors to amplify the transcription of target genes, engaging in cell proliferation, differentiation, and metabolic processes. NCOA4 is particularly instrumental in the modulation of sex hormone signaling and cell cycle regulation. Its dysregulation is linked to the genesis and progression of cancers such as breast and prostate, marking it as a promising target for oncological therapies. Additionally, NCOA4 contributes to energy metabolism and the pathogenesis of obesity-related conditions, making it a significant factor in metabolic disease research.