NFKB1, encoding the p50 subunit of the NF-κB/Rel protein family, is located on chromosome 3. It plays a role in various biological processes, including the regulation of innate and adaptive immunity, inflammation, stress response, B cell development, and lymphoid organogenesis. Within the cytoplasm, NF-κB is bound and inhibited by IκB proteins until stimulated by inflammatory factors, lipopolysaccharide (LPS), or growth factors, which activate the IKK complex. This activation leads to the phosphorylation and degradation of IκB, releasing the NF-κB/Rel complex to translocate to the nucleus and initiate the expression of target genes. NFKB1 is crucial for modulating immune responses and inflammation, and its abnormal activation is linked to a range of diseases, including autoimmune diseases, inflammatory conditions, and certain types of cancer, making it an important target for drug development.
Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) (CSB-EP015759HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Phospho-NFKB1 (Ser932) Antibody (CSB-PA142672)
Validated Data
Western blot analysis of extracts from 293 cells untreated or treated with TNF-a using NFkB-p105(Phospho-Ser932) Antibody.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p105(Phospho-Ser932) Antibody(left) or the same antibody preincubated with blocking peptide(right).
Human Nuclear factor-kappa B,NF-κB ELISA Kit (CSB-E12107h)
Validated Data
Code: CSB-E12107h
Size: 96T,5×96T,10×96T
Sensitivity: 0.078 ng/mL
Detection Range: 0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following NFKB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NFKB1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA10354B0Rb | NFKB1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA10354C0Rb | NFKB1 Antibody, FITC conjugated | Human | |
CSB-PA10354D0Rb | NFKB1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA015759GA01HU | NFKB1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA142672 | Phospho-NFKB1 (Ser932) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA283590 | Phospho-NFKB1 (Ser927) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA186775 | NFKB1 (Ab-337) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA108426 | NFKB1 (Ab-893) Antibody | Human | ELISA,WB,IHC |
CSB-PA696291 | NFKB1 (Ab-907) Antibody | Human | ELISA,WB,IHC |
CSB-PA190132 | NFKB1 (Ab-932) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA258273 | Phospho-NFKB1 (Ser893) Antibody | Human | ELISA,IHC,IF |
CSB-PA632717 | Phospho-NFKB1 (Ser337) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA925652 | Phospho-NFKB1 (Ser907) Antibody | Human | ELISA,WB,IHC |
CSB-PA000579 | Phospho-NFKB1 (S893) Antibody | Human | WB, IHC, ELISA |
CSB-PA000580 | Phospho-NFKB1 (S907) Antibody | Human | WB, IHC, IP, ELISA |
CSB-PA000581 | Phospho-NFKB1 (S932) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA000683 | Phospho-NFKB1 (S337) Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA000730 | Phospho-NFKB1 (S927) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA003430 | NFKB1 Antibody | Human | WB, IHC, IP, ELISA |
CSB-PA003431 | NFKB1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA003434 | NFKB1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA004763 | NFKB1 Antibody | Human | WB, ELISA |
CSB-PA020084 | Phospho-NFKB1 (S337) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA020085 | NFKB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020086 | NFKB1 Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA020090 | NFKB1 Antibody | Human | WB, IHC, ELISA |
CSB-PA020096 | NFKB1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA259078 | NFKB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA546304 | NFKB1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA441503 | NFKB1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA10354A0Rb | NFKB1 Antibody | Human | ELISA, WB, IHC, IF, ChIP |
NFKB1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP015759CH CSB-EP015759CH CSB-BP015759CH CSB-MP015759CH CSB-EP015759CH-B |
Recombinant Chicken Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015759HU1 CSB-BP015759HU1 CSB-MP015759HU1 CSB-EP015759HU1-B |
Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP103544h | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) | E.coli |
CSB-EP015759HU | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) | E.coli |
CSB-EP015759HU1 | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial | E.coli |
NFKB1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015759MO CSB-EP015759MO CSB-BP015759MO CSB-MP015759MO CSB-EP015759MO-B |
Recombinant Mouse Nuclear factor NF-kappa-B p105 subunit (Nfkb1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP723572RA CSB-EP723572RA CSB-BP723572RA CSB-MP723572RA CSB-EP723572RA-B |
Recombinant Rat Nuclear factor NF-kappa-B p105 subunit (Nfkb1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP739094DO CSB-EP739094DO CSB-BP739094DO CSB-MP739094DO CSB-EP739094DO-B |
Recombinant Dog Nuclear factor NF-kappa-B p105 subunit (NFKB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12107h | Human Nuclear factor-kappa B,NF-κB ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
NFKB1 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12108m | Mouse Nuclear factor-kappa B,NF-κB ELISA Kit | serum, plasma, cell culture supernates | 0.078 ng/mL |
NFKB1 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13148r | Rat Nuclear factor-kappa B(NF-κB) ELISA Kit |