Nuclear factor NF-kappa-B p105 subunit is a protein in humans that is encoded by NFKB1 gene. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity.
The following NFKB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NFKB1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA10354B0Rb | NFKB1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA10354C0Rb | NFKB1 Antibody, FITC conjugated |
Human | |
CSB-PA10354D0Rb | NFKB1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA015759GA01HU | NFKB1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA142672 | Phospho-NFKB1 (Ser932) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA283590 | Phospho-NFKB1 (Ser927) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA186775 | NFKB1 (Ab-337) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA108426 | NFKB1 (Ab-893) Antibody |
Human | ELISA,WB,IHC |
CSB-PA696291 | NFKB1 (Ab-907) Antibody |
Human | ELISA,WB,IHC |
CSB-PA190132 | NFKB1 (Ab-932) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA258273 | Phospho-NFKB1 (Ser893) Antibody |
Human | ELISA,IHC,IF |
CSB-PA632717 | Phospho-NFKB1 (Ser337) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA925652 | Phospho-NFKB1 (Ser907) Antibody |
Human | ELISA,WB,IHC |
CSB-PA000579 | Phospho-NFKB1 (S893) Antibody |
Human | WB, IHC, ELISA |
CSB-PA000580 | Phospho-NFKB1 (S907) Antibody |
Human | WB, IHC, IP, ELISA |
CSB-PA000581 | Phospho-NFKB1 (S932) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA000683 | Phospho-NFKB1 (S337) Antibody |
Human,Mouse | WB, IHC, ELISA |
CSB-PA000730 | Phospho-NFKB1 (S927) Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA003430 | NFKB1 Antibody |
Human | WB, IHC, IP, ELISA |
CSB-PA003431 | NFKB1 Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA003434 | NFKB1 Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA004763 | NFKB1 Antibody |
Human | WB, ELISA |
CSB-PA020084 | Phospho-NFKB1 (S337) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA020085 | NFKB1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020086 | NFKB1 Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-PA020090 | NFKB1 Antibody |
Human | WB, IHC, ELISA |
CSB-PA020096 | NFKB1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA259078 | NFKB1 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA546304 | NFKB1 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA441503 | NFKB1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA10354A0Rb | NFKB1 Antibody |
Human | ELISA, WB, IHC, IF, ChIP |
NFKB1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP015759CH CSB-EP015759CH CSB-BP015759CH CSB-MP015759CH CSB-EP015759CH-B |
Recombinant Chicken Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015759HU1 CSB-BP015759HU1 CSB-MP015759HU1 CSB-EP015759HU1-B |
Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP103544h | Recombinant Human Nuclear factor NF-kappa-B p105 subunit (NFKB1) |
E.coli |
NFKB1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015759MO CSB-EP015759MO CSB-BP015759MO CSB-MP015759MO CSB-EP015759MO-B |
Recombinant Mouse Nuclear factor NF-kappa-B p105 subunit (Nfkb1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP723572RA CSB-EP723572RA CSB-BP723572RA CSB-MP723572RA CSB-EP723572RA-B |
Recombinant Rat Nuclear factor NF-kappa-B p105 subunit (Nfkb1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP739094DO CSB-EP739094DO CSB-BP739094DO CSB-MP739094DO CSB-EP739094DO-B |
Recombinant Dog Nuclear factor NF-kappa-B p105 subunit (NFKB1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFKB1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12107h | Human Nuclear factor-kappa B,NF-κB ELISA Kit |
serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
NFKB1 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12108m | Mouse Nuclear factor-kappa B,NF-κB ELISA Kit |
serum, plasma, cell culture supernates | 0.078 ng/mL |
NFKB1 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13148r | Rat Nuclear factor-kappa B(NF-κB) ELISA Kit |
serum, plasma, tissue homogenates | 0.39 pg/mL |
Nuclear factor NF-kappa-B p105 subunit is a protein in humans that is encoded by the NFKB1 gene [1]. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis [2]. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL, and NFKB2/p52, and the heterodimeric p65-p50 complex appears to be most abundant one [3][4]. The dimers bind at kappa-B sites in the DNA of their target genes, and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity [3]. The NFKB1/p105 pathway involves the unprocessed NFKB1/p105 which preferentially binds to a homodimer of processed NFKB1/p50 [4]. The complex is inactive, and ubiquitinylation of p105 followed by destruction is required for the liberation of the processed NFKB dimer [5]. The importance of the NFKB1 function can be seen in mouse models, where NFKB1-null mice display increased inflammation and susceptibility to certain forms of DNA damage, leading to cancer, and a rapid aging phenotype [6].
[1] Meyer R, Hatada EN, et al. Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha [J]. Proc Natl Acad Sci U S A. 1991, 88 (3): 966–70.
[2] Perkins ND. Integrating cell‐signalling pathways with NF‐κB and IKK function. Nat Rev Mol Cell Biol 2007, 8, 49–62.
[3] Moynagh PN. The NF‐κB pathway. J Cell Sci 2005, 118, 4589–4592.
[4] Barkett M and Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene. 18:6910–6924. 1999.
[5] Kravtsova-Ivantsiv Y, Shomer I, et al. KPC1-mediated ubiquitination and proteasomal processing of NF-jB1 p105 to p50 restricts tumor growth. Cell 2015, 161, 333–347.
[6] Tyrell Cartwright, Neil D. Perkins, et al. NFKB1: a suppressor of inflammation, ageing and cancer [J]. FEBS Journal 283 (2016) 1812–1822.