NRP2

Neuropilin 2 (NRP2) is a transmembrane glycoprotein with several aliases such as FLJ12962 and MNR2. It plays crucial roles in axon guidance, angiogenesis, and immune cell function. Mechanistically, NRP2 binds to semaphorins and vascular endothelial growth factors (VEGFs), influencing cell migration and survival. It is involved in various signaling pathways like the VEGF-VEGFR2 pathway.
Dysregulation of NRP2 has been linked to multiple diseases including cancer, where it promotes tumor angiogenesis and metastasis. In the field of drug development, targeting NRP2 is an emerging strategy, with some small - molecule inhibitors and monoclonal antibodies under pre - clinical and clinical investigations to halt tumor progression.