PADI4

PIK3C3, Phosphatidylinositol 3-kinase catalytic subunit type 3, alias PAD4, PDI4, PDI5, PADI5. PIK3C3 is encoded by the human PADI4 gene, which is located on chromosome 1 in the p36.13 region.
PIK3C3 is a calcium-dependent enzyme that participates in protein citrullination, a post-translational modification of proteins, by catalyzing the process of converting arginine residues to citrulline residues. Post-translational modifications. PIK3C3 regulates gene transcriptional activity through histone citrullination and affects the onset and progression of a variety of diseases, including autoimmune diseases, tumors, and acute coronary syndromes. Abnormal regulation of PIK3C3 has been associated with a variety of diseases such as rheumatoid arthritis, tumor progression, and multiple sclerosis, and has been suggested as a potential therapeutic target for the treatment of these diseases.