PCNA

PCNA, short for Proliferating Cell Nuclear Antigen, is also commonly known as cyclin. This protein plays a vital role in DNA replication and repair. It functions as a sliding clamp that allows DNA polymerase to move along the DNA strand efficiently, ensuring the accuracy of DNA synthesis. PCNA is involved in the base - excision repair pathway.
Dysregulation of PCNA is associated with various diseases, including cancer. It serves as a biomarker for cell proliferation in tumors. In drug development, targeting PCNA is a promising strategy. Some small - molecule inhibitors are under research to disrupt its function, aiming to halt the proliferation of cancer cells and provide new therapeutic options.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PCNA Recombinant Monoclonal Antibody (CSB-RA017621MA1HU)

Validated Data

Overlay Peak curve showing JK cells stained with CSB-RA017621MA1HU (red line) at 1:300. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10⁶cells) used under the same conditions. Acquisition of >10, 000 events was performed.

The following PCNA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PCNA Antibodies

PCNA Proteins

PCNA Antibodies

PCNA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA017621GA01HU	PCNA Antibody	Human,Mouse,Rat,Zebrafish	ELISA,WB,IHC,IF
CSB-PA974334	PCNA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA003719	PCNA Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA01567A0Rb	PCNA Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA01567B0Rb	PCNA Antibody, HRP conjugated	Human	ELISA
CSB-PA01567C0Rb	PCNA Antibody, FITC conjugated	Human
CSB-PA01567D0Rb	PCNA Antibody, Biotin conjugated	Human	ELISA
CSB-RA017621MA1HU	PCNA Recombinant Monoclonal Antibody	Human	ELISA, FC

PCNA Antibodies for H, R, M

Code	Product Name	Species Reactivity	Application
CSB-MA000186	PCNA Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB,IHC

PCNA Antibodies for Arabidopsis thaliana

Code	Product Name	Species Reactivity	Application
CSB-PA878702LA01DOA	PCNA Antibody	Arabidopsis thaliana	ELISA, WB

PCNA Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA878702LC01DOA	PCNA Antibody, FITC conjugated	Arabidopsis thaliana
CSB-PA878702LD01DOA	PCNA Antibody, Biotin conjugated	Arabidopsis thaliana	ELISA

PCNA Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA017621XA01DLU	PCNA Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

PCNA Antibodies for Zea mays (Maize)

Code	Product Name	Species Reactivity	Application
CSB-PA017621XA01ZAX	PCNA Antibody	Zea mays (Maize)	ELISA, WB (ensure identification of antigen)

PCNA Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA017621XA01DIL	pcna Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

PCNA Proteins

PCNA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP017621HU CSB-BP017621HU CSB-MP017621HU CSB-EP017621HU-B	Recombinant Human Proliferating cell nuclear antigen (PCNA)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP017621HU	Recombinant Human Proliferating cell nuclear antigen (PCNA)	E.coli

PCNA Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP017621MO CSB-EP017621MO CSB-BP017621MO CSB-MP017621MO CSB-EP017621MO-B	Recombinant Mouse Proliferating cell nuclear antigen (Pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP017621RA CSB-EP017621RA CSB-BP017621RA CSB-MP017621RA CSB-EP017621RA-B	Recombinant Rat Proliferating cell nuclear antigen (Pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for BOMMO(Silk moth)

Code	Product Name	Source
CSB-YP017621BTT CSB-EP017621BTT CSB-BP017621BTT CSB-MP017621BTT CSB-EP017621BTT-B	Recombinant Bombyx mori Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Sarcophaga crassipalpis

Code	Product Name	Source
CSB-YP017621SXH CSB-EP017621SXH CSB-BP017621SXH CSB-MP017621SXH CSB-EP017621SXH-B	Recombinant Sarcophaga crassipalpis Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Pisum sativum (Garden pea)

Code	Product Name	Source
CSB-YP017621EWE CSB-EP017621EWE CSB-BP017621EWE CSB-MP017621EWE CSB-EP017621EWE-B	Recombinant Pisum sativum Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Nicotiana tabacum (Common tobacco)

Code	Product Name	Source
CSB-YP017621NHE CSB-EP017621NHE CSB-BP017621NHE CSB-MP017621NHE CSB-EP017621NHE-B	Recombinant Nicotiana tabacum Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP017621XBE CSB-EP017621XBE CSB-BP017621XBE CSB-MP017621XBE CSB-EP017621XBE-B	Recombinant Xenopus laevis Proliferating cell nuclear antigen (pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP017621DLU CSB-EP017621DLU CSB-BP017621DLU CSB-MP017621DLU CSB-EP017621DLU-B	Recombinant Drosophila melanogaster Proliferating cell nuclear antigen (mus209)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Plasmodium falciparum (isolate K1 / Thailand)

Code	Product Name	Source
CSB-YP017621EWT CSB-EP017621EWT CSB-BP017621EWT CSB-MP017621EWT CSB-EP017621EWT-B	Recombinant Plasmodium falciparum Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Styela clava (Sea squirt)

Code	Product Name	Source
CSB-YP017621FOV CSB-EP017621FOV CSB-BP017621FOV CSB-MP017621FOV CSB-EP017621FOV-B	Recombinant Styela clava Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

Code	Product Name	Source
CSB-YP017621DXU CSB-EP017621DXU CSB-BP017621DXU CSB-MP017621DXU CSB-EP017621DXU-B	Recombinant Cricetulus griseus Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Plasmodium falciparum (isolate 3D7)

Code	Product Name	Source
CSB-YP017621EWP CSB-EP017621EWP CSB-BP017621EWP CSB-MP017621EWP CSB-EP017621EWP-B	Recombinant Plasmodium falciparum Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP017621MOV CSB-EP017621MOV CSB-BP017621MOV CSB-MP017621MOV CSB-EP017621MOV-B	Recombinant Macaca fascicularis Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Autographa californica nuclear polyhedrosis virus (AcMNPV)

Code	Product Name	Source
CSB-YP318812ARA CSB-EP318812ARA CSB-BP318812ARA CSB-MP318812ARA CSB-EP318812ARA-B	Recombinant Autographa californica nuclear polyhedrosis virus Probable DNA polymerase sliding clamp (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV)

Code	Product Name	Source
CSB-YP517500OEU CSB-EP517500OEU CSB-BP517500OEU CSB-MP517500OEU CSB-EP517500OEU-B	Recombinant Orgyia pseudotsugata multicapsid polyhedrosis virus Probable DNA polymerase sliding clamp (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-YP017621DKK CSB-EP017621DKK CSB-BP017621DKK CSB-MP017621DKK CSB-EP017621DKK-B	Recombinant Dictyostelium discoideum Proliferating cell nuclear antigen (pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni)

Code	Product Name	Source
CSB-YP017621HSH CSB-EP017621HSH CSB-BP017621HSH CSB-MP017621HSH CSB-EP017621HSH-B	Recombinant Haplochromis burtoni Proliferating cell nuclear antigen (pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP017621DIL CSB-EP017621DIL CSB-BP017621DIL CSB-MP017621DIL CSB-EP017621DIL-B	Recombinant Danio rerio Proliferating cell nuclear antigen (pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP017621CH CSB-EP017621CH CSB-BP017621CH CSB-MP017621CH CSB-EP017621CH-B	Recombinant Chicken Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Populus nigra (Lombardy poplar)

Code	Product Name	Source
CSB-YP017621PPT CSB-EP017621PPT CSB-BP017621PPT CSB-MP017621PPT CSB-EP017621PPT-B	Recombinant Populus nigra Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)

Code	Product Name	Source
CSB-YP017621DXJ CSB-EP017621DXJ CSB-BP017621DXJ CSB-MP017621DXJ CSB-EP017621DXJ-B	Recombinant Coturnix coturnix japonica Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Anguilla japonica (Japanese eel)

Code	Product Name	Source
CSB-YP017621BZH CSB-EP017621BZH CSB-BP017621BZH CSB-MP017621BZH CSB-EP017621BZH-B	Recombinant Anguilla japonica Proliferating cell nuclear antigen (pcna)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP017621BO CSB-EP017621BO CSB-BP017621BO CSB-MP017621BO CSB-EP017621BO-B	Recombinant Bovine Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Zea mays (Maize)

Code	Product Name	Source
CSB-YP017621ZAX CSB-EP017621ZAX CSB-BP017621ZAX CSB-MP017621ZAX CSB-EP017621ZAX-B	Recombinant Zea mays Proliferating cell nuclear antigen (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Acanthamoeba polyphaga mimivirus (APMV)

Code	Product Name	Source
CSB-YP745851ADAZ CSB-EP745851ADAZ CSB-BP745851ADAZ CSB-MP745851ADAZ CSB-EP745851ADAZ-B	Recombinant Acanthamoeba polyphaga mimivirus Probable DNA polymerase sliding clamp (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PCNA Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP878702DOA CSB-EP878702DOA CSB-BP878702DOA CSB-MP878702DOA CSB-EP878702DOA-B	Recombinant Arabidopsis thaliana Proliferating cellular nuclear antigen 1 (PCNA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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