PFKFB3

PFKFB3, fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase 3, alias PFK2/ IPFK2/ iPFK-2, is an enzyme that plays a key role in cellular glycolysis.PFKFB3 catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, which is a potent glycolysis-promoting factor that activates the glycolytic pathway. The source of PFKFB3 is the gene encoded by human cells themselves, and it is expressed in a variety of cell types, especially in immune cells and tumor cells.The mechanism of action of PFKFB3 involves the regulation of the glycolytic pathway, which affects cellular metabolic status and function by regulating the level of its metabolites.

The biological significance is mainly in its regulation of cellular metabolism and inflammatory responses. In inflammatory and immune responses, PFKFB3 meets the increased cellular demand for energy and biomolecules by promoting glycolysis. In addition, PFKFB3 activity is associated with multiple signaling pathways, such as the HIF-1α and NF-κB signaling pathways, which play key roles in cell proliferation, migration, expression of inflammatory factors, and tumor development. Studies have indicated that abnormalities in the expression or activity of PFKFB3 are associated with the development of serious diseases such as diabetes, pulmonary hypertension, and sepsis, making PFKFB3 a potential target in drug development, which by regulating its activity may provide new strategies for the treatment of related diseases.

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Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)