PPP2CA

PPP2CA encodes the protein phosphatase 2 catalytic subunit alpha isoform (PP2A-Cα), a critical serine/threonine phosphatase. It forms heterotrimeric complexes with regulatory and structural subunits to dephosphorylate target proteins, governing cell cycle progression, apoptosis, and DNA damage repair.
PP2A-Cα modulates key pathways including Wnt, PI3K/Akt, and MAPK. Dysregulation (mutations or reduced expression) links to cancers (lung, breast) and neurodegenerative disorders like Alzheimer’s. Preclinical studies explore PP2A activators (e.g., FTY720 derivatives) as potential therapies, though clinical trials remain limited.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PPP2CA Antibody (CSB-PA018559LA01HU)

Validated Data

Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue
All lanes: PPP2CA antibody at 2.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36, 30 kDa
Observed band size: 36, 30 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA018559LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA018559LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following PPP2CA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PPP2CA Antibodies

PPP2CA Proteins

PPP2CA Antibodies

PPP2CA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA018559GA01HU	PPP2CA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA574686	PPP2CA Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA003834	PPP2CA Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA030181	Phospho-PPP2CA (Y307) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA114505	PPP2CA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA318216	PPP2CA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA018559LA01HU	PPP2CA Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA018559LB01HU	PPP2CA Antibody, HRP conjugated	Human	ELISA
CSB-PA018559LC01HU	PPP2CA Antibody, FITC conjugated	Human
CSB-PA018559LD01HU	PPP2CA Antibody, Biotin conjugated	Human	ELISA
CSB-RA018559A307phHU	Phospho-PPP2CA (Y307) Recombinant Monoclonal Antibody	Human	ELISA, WB

PPP2CA Proteins

PPP2CA Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP018559BO CSB-EP018559BO CSB-BP018559BO CSB-MP018559BO CSB-EP018559BO-B	Recombinant Bovine Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PPP2CA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP018559HU CSB-BP018559HU CSB-MP018559HU CSB-EP018559HU-B	Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP018559HU	Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	E.coli
CSB-EP018559HUc7	Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	E.coli
CSB-EP018559HUa0	Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	E.coli

PPP2CA Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP018559RB CSB-EP018559RB CSB-BP018559RB CSB-MP018559RB CSB-EP018559RB-B	Recombinant Rabbit Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PPP2CA Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP018559PI CSB-EP018559PI CSB-BP018559PI CSB-MP018559PI CSB-EP018559PI-B	Recombinant Pig Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PPP2CA Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP018559CH CSB-EP018559CH CSB-BP018559CH CSB-MP018559CH CSB-EP018559CH-B	Recombinant Chicken Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PPP2CA Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP018559MO CSB-EP018559MO CSB-BP018559MO CSB-MP018559MO CSB-EP018559MO-B	Recombinant Mouse Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (Ppp2ca)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PPP2CA Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP018559RA CSB-EP018559RA CSB-BP018559RA CSB-MP018559RA CSB-EP018559RA-B	Recombinant Rat Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (Ppp2ca)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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PPP2CA

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